【科技前瞻】Cell Mol Gastroenterol Hepatol:揭示神经降压素在肠道干细胞功能中扮演关键角色 肠道上皮细胞每4至5天就会发生一次完全的更替,这种快速的自我更新过程由位于肠隐窝底部的肠干细胞(intestinal stem cells,ISCs)维持。ISCs对膳食改变...
近日,山东大学基础医学院马春红教授在Cellular and Molecular Gastroenterology and Hepatology上发表了以cccDNA surrogate MC-HBV-based screen identifies cohesin complex as a novel HBV restriction factor为题的研究成果。 为探寻阻断HBV复制的...
附属北京友谊医院张栋教授团队《Cell Mol Gastroenterol Hepatol》阐释双阴性T细胞不同亚群影响非酒精性脂肪性肝病的机制 2022年4月,首都医科大学附属北京友谊医院张栋教授与孙广永副教授团队在《Cellular and Molecular Gastroenterology and Hepatology》上发表题为“The Critical and Diverse Roles of CD4– CD8– Double ...
综上所述，该研究在单细胞分辨率系统地揭示了人类胃体上皮细胞的基因表达特征和表观遗传学调控特征，鉴定了胃上皮干/组细胞的重要调控基因FABP5和NME1，确认了EGF和WNT信号通路对于维持胃上皮干/组细胞的重要功能，为未来相关疾病特别是胃癌的诊断和治疗提供了潜在的帮助。北京大学生物医学前沿创新中心汤富酬教授与北医...
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