Hepatocellular carcinoma (HCC) is one of the most malignant solid tumors worldwide. Recent evidence shows that the stimulator of interferon genes (STING) pathway is essential for anti-tumor immunity via inducing the production of downstream inflammatory
Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury. J Neuroinflammation. 2023;20(1):296. Article PubMed PubMed Central CAS Google Scholar Wu J, Sun Z, Yang S, et al. Kidney single-cell transcriptome prole reveals ...
Despite the complexities in understanding mitochondrial dysfunction due to its multifaceted nature and elusive phenotype threshold, mitochondria remain a crucial therapeutic target, particularly as most renal mitochondria are found in the proximal tubules and TAL cells at the outer medulla-cortical medulla j...
The fusion protein MfN1 (mitofusin 1/2) and fission protein FIS1 (mitochondrial fission protein 1) play a key role in erythropoiesis. Overexpression of FIS1 leads to the breakdown of the mitochondrial net, which inhibits both hemoglobin biosynthesis and erythroid differentiation, keeping cells in ...
proteins, such as mitofusin 1 (MFN1), mitofusin 2 (MFN2), ras homolog family member T (RHOT/MIRO), voltage-dependent anion channel (VDAC), and BAK, thus forming a positive feedback loop that amplifies the original signal, leading to extensive Parkin recruitment and ubiquitination [44, 51,...
Material and methods Cell lines and tissue samples Two human HNSCC cell lines (AMC-HN-8 and Cal27) and one murine HNSCC line (SCC7) were acquired from the National Collection of Authenticated Cell Cultures (Shanghai, China). All cells were cultured in Dulbecco's mod ified eagle medium...
Smed-mfn1,Smed-mfn2, mitochondrial fission genesSmed-drp1andSmed-fis1, and mitochondrial transportation geneSmed-miro-1(henceforth referred to asopa1,mfn1,mfn2,drp1,fis1, andmiro-1) (Supplementary Data1). Bacteria expressing dsRNA were used to feed planarians to knock down gene expression, ...
(A) UALCAN analysis for the correlation between SIRT3 mRNA expression and human gastric adenocarcinoma; p < 1E-12 for Normal-vs-Primary tumor. (B) SIRT3 expression in gastric cancer and normal tissues from the Human Protein Atlas (HPA) database. Immunohistochemical staining done with antibody ...
IscU2 is a scaffold protein that is critical for the assembly of iron–sulfur (Fe–S) clusters and the functions of Fe–S-containing mitochondrial proteins. However, the role of IscU2 in tumor development remains unclear. Here, we demonstrated that IscU2
[33]. Studies have shown that exposure to high glucose or palmitate can lead to the downregulation of MFN1 and upregulation of DRP1 in renal cells, indicating altered mitochondrial dynamics and increased mitochondrial division [34]. Patients with DKD also exhibit increased mitochondrial division, ...