Keratoconus is a common ectatic corneal disorder in adolescents and young adults that can lead to progressive visual impairment or even legal blindness. Despite the high prevalence, its etiology is not fully understood. In this study, we performed single
Cell cycle analysis allows us to evaluate whether DDX59 could promote cells entry into S phase. As shown by Figure 5, we found that in three DDX59 knockdown samples, cells demonstrated significant reduction in DNA synthesis. Figure 5 DDX59 deficiency leads to cell cycle arrest. (a) H1299 ...
Cervical cancer (CC) is a leading cause of cancer-related death among women in developing countries. However, the underlying mechanisms and molecular targe
S-1 is a new oral fluoropyrimidine derivative designed to enhance anticancer activity and reduce gastrointestinal toxicity. This phase II trial aimed to evaluate S-1 in patients with relapsed small cell lung cancer (SCLC). SCLC patients who had experienced treatment failure with ≥1 prior chemother...
Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. B cells are crucial factors in tumor suppression, and tertiary lymphoid structures (TLSs) facilitate immune cell recruitment to the tumor microenvironment (TME).
Sun, Y.-M., S.-X. Zhu, X.-T. Chen, Q. Pan, Y. An, T.-Q. Chen, H.-J. Huang, K.-J. Pu, J.-Y. Lian, W.-L. Zhao,W.-T. WangandY.-Q. Chen(2024). "lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing." Molecular...
If the enzymes were made all the time, the cell would be inefficient in an environment devoid of the substrates of the enzymes [9]. In this study, we are motivated to apply the theory of multivariate phase synchronization to cell-cycle-specific gene expression data. Synchronization is one of...
Somatic embryogenesis is a major process for plant regeneration. However, cell communication and the gene regulatory network responsible for cell reprogramming during somatic embryogenesis are still largely unclear. Recent advances in single-cell technol
Exeliom Biosciences announces three phase II clinical trials in immuno-oncology with lead candidate combined with immune checkpoint inhibitors 2024-04-11 , pharmiweb Seed Health推出计算生物学平台CODA,用于挖掘新益生菌 ① 4月11日,Seed Health公司宣布推出计算生物学平台CODA,用于研究和开发下一代精准益生...
To investigate the specific regulatory mechanisms ofLINC00511in promoting cell proliferation, flow cytometry (cell cycle distribution) analysis revealed that the knockdown ofLINC00511expression significantly decreased the proportion of UACC-812 and MDA-MB-231 cells in S phase. In contrast, the overexpres...