Protein phase separation: new insights into cell divisiondoi:10.3724/abbs.2023093Hongdan ZhengWenyu WenActa Biochimica et Biophysica Sinica
Computational models have made significant progress in predicting the effect of protein variants. However, deciphering numerous variants of uncertain significance (VUS) located within intrinsically disordered regions (IDRs) remains challenging. To address this issue, we introduce phase separation, which is...
Z. Phase separation in cell division. Mol. Cell 80, 9–20 (2020). Article CAS PubMed PubMed Central Google Scholar Musacchio, A. On the role of phase separation in the biogenesis of membraneless compartments. EMBO J. 41, e109952 (2022). Article CAS PubMed PubMed Central Google ...
... & Vale, R. D. (2016). Phase separation of signaling molecules promotes T cell receptor s...
(2) was derived for segregative phase separation, we expect shifts of the critical point toward the overall composition to generally reduce interfacial tension. In other words, we expect droplets to swim to their dissolution. We call this process dialytaxis, from the Ancient Greek\(\delta \...
Phase Separation of Scaffold Protein Regulates Microbial Asymmetric Cell Division By polarizing different cell fate determinants at opposite cell poles, asymmetric cell division (ACD) that produces distinct daughter cells is an evolutiona...
(G1, S, and G2) are included in theinterphaseperiod. Cells spend most of their time in interphase, duringwhich they perform their normal metabolic functions. The fourth phase, called M (mitosis), is shorter. In this phase, cell division andchromatidseparation takes place to form two new ...
Liquid–liquid phase separation (LLPS) in biology describes a process by which proteins form membraneless condensates within a cellular compartment when conditions are met, including the concentration and posttranslational modifications of the protein co
Chemical freezing of phase separation in immiscible binary mixtures. Phys. Rev. E 56, 3127–3136 (1997). Article CAS Google Scholar Bazant, M. Z. Thermodynamic stability of driven open systems and control of phase separation by electro-autocatalysis. Faraday Discuss. 199, 423–463 (2017). ...
Material properties of phase-separated biomolecular condensates, enriched with disordered proteins, dictate many cellular functions. Contrary to the progress made in understanding the sequence-dependent phase separation of proteins, little is known about the sequence determinants of condensate material propertie...