Noninvasive prenatal screening for fetal aneuploidy with the use of cell-free DNA (cfDNA) is a screening method that offers high sensitivity and specificity in validation studies and has reduced the need for unnecessary invasive procedures. Laboratories often advertise and report a test's sensitivity...
A new type of prenatal screening however, offers parents-to-be a better option. Cell-Free Fetal DNA testing detects chromosomal abnormalities through a simple blood test that is more accurate than current screening tests and can be done earlier in pregnancy—as early as the 10th week, with r...
aCell-free fetal DNA in maternal plasma presents interest as it can possibly serve as a pregnancy associated biomarker. For its quantitation, we investigate the use of fluorescent polymerase chain reaction (PCR) amplification of short tandem repeats (STRs) in pregnancies irrespective of sex. 当它...
The test performance and test failure (no-call) rates were assessed for the cohort, and women with low and high previous risks for aneuploidy were compared. An updated cell-free DNA algorithm blinded to the pregnancy outcome was also assessed. Results A total of 20,194 women were enrolled ...
In families with X-linked recessive diseases, foetal sex is determined prenatally by detection of Y-chromosomal sequences in cell-free foetal DNA (cffDNA) in maternal plasma. The same procedure is used to confirm the cffDNA presence during non-invasive p
Cell-free fetal DNA (cff-DNA) is a novel promising biomarker that has been applied in various aspects of obstetrical research, notably in prenatal diagnosis and complicated pregnancies. It is easily detected by semi-quantitative PCR for the SRY target gene. It is well recognized that the levels...
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance of blood-based early cancer detection. However, integrative profiling of cfDNA methylome and fragmentome has been technologically challenging. Here, we adapt an enzyme-mediated methylation sequencing method for com...
cell-free DNAfirst trimester pregnancyNIPTprenatal screeningObjective: First, to assess what was the uptake of cell free DNA (cfDNA) testing after a combined test and the maternal and fetal factors that influenced this decision, and second, to assess the uptake and factors that influence the ...
近期,来自耶鲁医学院科研团队在Cell Metabolism杂志发表了一篇名为:The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging的文章。科学家们分析了119名孕产妇在怀孕/生产不同时间点的血液...
Cell-free DNA is higher and more fragmented in intrahepatic cholestasis of pregnancy.Cell-free DNA is higher and more fragmented in intrahepatic cholestasis of pregnancy.doi:10.1002/pd.4952BarboraVlkováMartaKalousováAnnaGermanováAntonínPa?ízekZdeněk...