LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity AG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T...
ADCC,antibody-dependent cell-mediated cytotoxicity抗体依赖的细胞介导的细胞毒性作用是指表达___的NK细胞、巨噬细胞和中性粒细胞等,通过与已结合在病毒感染细胞和肿瘤细胞等靶细胞表面的IgG抗体的Fc段结合,而杀伤这些靶细胞的作用。 连锁不平衡:HLA复合体等位基因在人群中有各自的基因频率,随机婚配的群体中,在无新...
8.Ruscetti, M., et al., NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science, 2018. 362(6421): p. 1416-1422.9.Provenzano, P.P., et al., Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal ...
细胞内吞(endocytosis)是指细胞外物质通过膜内陷和内化进入细胞的过程。主要分为吞噬(phagocytosis,内吞物为固体)和胞饮(pinocytosis,内吞物为液体),以及由微粒和细胞表面的性质决定的内吞作用。 ADCC(antibody-dependent cell-mediatedcytotoxicity)是指抗体依赖的细胞介导的细胞毒性作用,是抗肿瘤的治疗性抗体药物发生作用...
2023年6月13日,广东省智能科学与技术研究院(简称:广东省智能院)张旭研究团队在国际著名学术期刊《Cell Research》(细胞研究)上发表了题为“A direct spino-cortical circuit bypassing the thalamus modulates nociception”的论文,该研究综合利用神经环路示踪、电镜、钙成像、行为学等实验方法,发现了一条新的传导痛觉的...
LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity AG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity ...
近日,发表在国际杂志Cell上的研究报告中,来自匹兹堡大学等机构的科学家们通过研究揭示了靶向作用免疫检查点PD1和LAG3的免疫疗法如何共同发挥作用来激活宿主机体的免疫反应,相关研究结果揭示了为何靶向作用两种检查点的组合性疗法相比仅作用PD1的单一疗法能改善黑色素瘤患者的治疗结局。
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Antibody-dependent Cellular Cytotoxicity;Cytotoxicity, Mechanisms of;Delayed-type Hypersensitivity;Granuloma;Immunopathology;Parasites, Immunity to;Vaccines. View chapter Review article Autoimmune hepatitis: evolving concepts Autoimmunity ReviewsJournal2004,Autoimmunity Reviews ...