Although RIPK1 (receptor-interacting protein kinase 1)- and RIPK3-MLKL (mixed lineage kinase domain-like)-mediated necroptosis is the most understood form of regulated necrosis, other examples of this process are emerging, including cell death mechanisms known as parthanatos, oxytosis, ferroptosis,...
Cell death terminates normal cellular functions, including respiration, metabolism, growth and proliferation. Cell death can be non-programmed, for example as the result of accidental injury or trauma, or programmed. Types of programmed cell death include anoikis, apoptosis, autophagy, necrosis, necropt...
This depletion leads to the activation of processes like chromatin condensation and DNA fragmentation, ultimately triggering a form of cell death known as parthanatos (Fatokun, Dawson, and Dawson, 2014). 3. Role of RCDs in aging and aging-related diseases Despite recent advances in modern ...
13). If any such essential molecule were targeted, death may occur, and such death need not fall into a known ptosis. In short, there are so many ways for a cell to die simply because there are so many things that function to keep it alive. As may already be apparent, herein I ...
1.7. Other Modes of Cell Death Other forms of cell death such as NETosis, parthanatos, entotic cell death, and lysosome-dependent cell death have been described in the literature, which are not covered here due to the lack of robust data on these cell death subroutines in liver diseases [...
Neutrophils undergo rapid aging and death known as constitutive or spontaneous death. Constitutive neutrophil death (CND) contributes to neutrophil homeostasis and inflammation resolution. CND has long been considered to be apoptotic until our findings reveal that it was a heterogeneous combination of dive...
Hepatocellular Carcinoma (HCC), the most common primary liver cancer, ranks as the third most common cause of cancer-related deaths globally. A deeper understanding of the cell death mechanisms in HCC is essential for developing more effective treatment
Renal cell carcinoma (RCC) is not sensitive to conventional radio- and chemotherapies and is at least partially resistant to impairments in cell death-related signaling pathways. The hallmarks of RCC formation include diverse signaling pathways, such as
Cell death articles withinCell Death & Disease Featured Article 19 May 2025|Open Access Deferiprone protects against photoreceptor degeneration by inhibiting parthanatos Beatriz Villarejo-Zori ,Juan Zapata-Muñoz &Patricia Boya Article 19 May 2025|Open Access ...
Cell death research was revitalized by the understanding that necrosis can occur in a regulated and genetically controlled manner. Although necroptosis is the most recognized form of regulated necrosis, other examples of this process have emerged. Unders