Cell deathis not only a physiological process occurring during organism development and tissue homeostasis, but also a pathological event implicated in tissue injury and dysfunction. Over the last few decades, the Nomenclature Committee on Cell Death has published several guidelines on the definition, d...
Inflammation is a key homeostatic process elicited by microbial components and by tissue damage. Increasing evidence indicates that the outcomes either tissue repair or persistent inflammatory damage and degeneration tightly depend on the pattern of cell death in situ and on infiltrating leukocytes and ...
They can die either during development, or as a result of stressful events, such as metabolic disruption, pathogenic invasion, or physiological tissue damage. Types of Cell Death: Apoptosis, Autophagy, and Necrosis Decades of research have allowed for the detailed characterization and classification ...
This is referred to as the ‘apoptosis–necrosis continuum.’ Two features influencing the position of this continuum are the availability of caspases and intracellular ATP. The path by which a cell dies is controlled in part by the nature of the death signal, type of tissue, and the ...
摘要: Bedridden and immobilized patients as well as those wearing prostheses are sensitive to the development of pressure sores (decubitus or pressure ulcers). Pressure sores are sites of restricted tissue degeneration of the skin or underlying tissues, such as subcutaneous...
This could be partly ascribed to our limited understanding of the complex cell death mechanism in the process of AKI. Necroptosis is a recently identified novel form of cell death contributing to numerable diseases and tissue damages8,9,10,11. Increasing evidence has suggested that necroptosis has...
Innate immune sensing of cell death in disease and therapeutics Man and Kanneganti discuss how pattern-recognition sensors in innate immune cells recognize and respond to cell-death signatures, and highlight molecular targets for potential therapeutic development. Si Ming Man Thirumala-Devi Kanneganti...
First, morphological signs of necrosis are not apparent until autolysis has developed in the necrotic tissue, and this takes 12-24 hours. Second, following death of the individual (sommatic death), all cells of the body will in time die due to lack of blood supply and postmortem autolysis ...
Although most cell death in animals are mediated by apoptosis, in some cases macroautophagy (referred to as autophagy) can be adapted as a mechanism of cell or tissue deletion [1]. Autophagy is an evolutionarily conserved process whereby cytoplasmic components are engulfed in a double-membrane ves...
Some modes of cell death are considered pro-inflammatory, e.g., pyroptosis and necrosis, and are mostly associated with microbial infections and pathogenic conditions that lead to significant tissue damage. Other modes of cell death are considered to be immunologically silent, such as apoptosis and...