Here we use single-cell Hi-C (high-resolution chromosome conformation capture) analysis to study chromosome conformations in thousands of individual cells, and discover a continuum of cis-interaction profiles that finely position individual cells along the cell cycle. We show that chromosomal ...
cell-cycle dynamics of chromosomal organisation at single-cell resolution Cell-cycle dynamics of chromosomal Organization at Single-Cell Resolution. Nature. 2017;547(7661):61-7.Nagano, T. et al. Cell-cycle dynamics of chromosomal organization at single-cell resolution. Nature 547, 61-67 (2017)....
Randy Wayne, in Plant Cell Biology (Second Edition), 2019 16.6 Cell Cycle The cell cycle is a term that describes the changes that occur through the life cycle of a cell, and, like most cellular processes, it is influenced by environmental conditions (Uchida and Furuya, 1997). The cell ...
During cerebral development, many types of neurons are sequentially generated by self-renewing progenitor cells called apical progenitors (APs). Temporal changes in AP identity are thought to be responsible for neuronal diversity; however, the mechanisms
Repetition of the cell cycle may produce a clone of identical cells, such as a colony of baker's yeast on a petri dish, or it may be accompanied by intricate changes that led to differentiation into distinctive cell types, or ultimately to the development of a complex organism. In all cas...
Cell cycle analysis using flow cytometry is a common technique for estimating the percentage of cell populations in different stages of the cell cycle. From: Translational Radiation Oncology, 2023 About this pageSet alert Also in subject areas: Biochemistry, Genetics and Molecular Biology Medicine and...
Centromeric chromatin consists of CenH3CENP-A nucleosomes interspersed with H3.1 and H3.3 nucleosomes, forming a unique biochemical environment that changes during the cell cycle and is tightly regulated. Chromosomes in species with regional centromeres (including humans and a large portion of eukaryot...
Yong demonstrated that treatment with Linagliptin of HCT116 cells prevented the growth of colorectal cancer tumor cells, causing cell cycle arrest and inducing apoptosis [12]. Beklen used differential interactome-based drug repositioning to identify potential drug candidates for CRC treatment, including ...
Increased expression of Ets2 has been associated with initiation and progression of various cancer types [62–65] and its expression was altered in cervical cancer cell lines due to chromosomal changes in 21q22.1–22.2 where human ETS2 resides [66]. Moreover, Ets2 was found overexpressed in ...
Accurate chromosome segregation during meiosis is crucial for reproduction. Human and porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly and subsequent chromosome segregation. The mechanism and function of chromoso