APC/C is a cell cycle-regulated E3 ubiquitin ligase that promotes ubiquitination of a distinct set of cell cycle proteins containing either a D-box (destruction box) or a KEN-box, named after the essential Lys-Glu-Asn motif required for APC recognition (13). Among its well-known substrates...
python bioinformatics analysis clustering gene-expression data-visualization dimensionality-reduction awesome-list data-integration atac-seq single-cell rna-seq-data scrna-seq-data cell-cycle cell-differentiation gene-expression-profiles analysis-pipeline cell-populations rna-seq-experiments cell-clusters Resour...
On the basis of knowledge about the cell cycle and gene expression regulation, the first therapeutic proteins were produced using mammalian cell cultures. The end of twentieth century and early twenty‐first century brought the progress in 3‐D cell culture technology and created the possibility of...
In-cell nanoelectronics for opening the door to intracellular electrophysiology. In-cell nanoelectronics are developed based on the interaction of design optimization and practical application: the continuous optimization of nano-biointerfaces, nanodevices and penetration strategies promotes intracellular electrophys...
Computational trajectory inference enables the reconstruction of cell state dynamics from single-cell RNA sequencing experiments. However, trajectory inference requires that the direction of a biological process is known, largely limiting its application
scPrisma manipulates the cell cycle signal in HeLa cells We first tested our approach on a scRNA-seq dataset of HeLa cells, unsynchronized across the cell cycle13(Fig.2). To assess the results, we used a list of approximately 400 genes, classified according to cell cycle phases13, where fo...
384A striking feature of theviral genomeis the presence of genes with homology to cell cycle regulatory and signaling proteins including complementbinding proteins,bcl-2, IL-6, IL-8 receptor,nerve cell adhesion molecule(N-CAM) family protein,macrophage inflammatory proteins(MIP-I, MIP-II),cyclin...
flip-flop (as shown inFigure 3-2) or a level-sensitive latch, whether it is to be triggered by a positive- or negative-going clock edge (in the case of the flip-flop option) or an active-low or active-high enable (if the register is instructed to act as a latch), and whether ...
PU.1 directly activates antiapoptotic Bcl-2A1 to support cell survival during neutrophil differentiation.8 The role of PU.1 can be extended to the commitment and maintenance of stem cells trough regulating the transcription of several cell cycle regulators.9 Recently, we linked PU.1 to the intrac...
CARD9 contributes to ovarian cancer cell proliferation, cycle arrest, and cisplatin sensitivity Article Open access 28 November 2022 Introduction High-grade serous ovarian cancer (HGSOC), which accounts for up to 70% of epithelial ovarian cancer, is a complex, heterogeneous disorder, and remains ...