The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. Oncogene. 2004; 23 :4353–4361.Castedo M, Perfettini JL, Roumier T, Yakushijin K, Horne D et al. (2004) The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe . Oncogene ...
细胞周期检查点(Cell cycle checkpoints)是为了确保细胞在复制过程中的完整性和保真度。真核生物存在四个重要的细胞检查点,分别为G1/S Checkpoint,Intra-S checkpoint,G2/M checkpoint,Spindle assembly checkpoint(SAC)。 G1/S Checkpoint 在生长因子的刺激下,细胞从休眠状态中脱离并进入G1期。这些刺激驱动细胞通过...
细胞周期检查点(Cell cycle checkpoints)是为了确保细胞在复制过程中的完整性和保真度。真核生物存在四个重要的细胞检查点,分别为G1/S Checkpoint,Intra-S checkpoint,G2/M checkpoint,Spindle assembly checkpoint(SAC)。 G1/S Checkpoint 在生长因子的刺激下,细胞从休眠状态中脱离并进入G1期。这些刺激驱动细胞通过...
Liu W, Zhong B, Zhang Y, Choi G: Mutation analysis of the checkpoint kinase 2 gene in colorectal cancer cell lines. Chinese Med 2007, 120: 2119-2123.Liu, W., Zhong, B., Zhang, Y., Choi, G.: Mutation analysis of the checkpoint kinase 2 gene in colorectal cancer cell lines. ...
3) cell cycle/checkpoint kinase 细胞周期/细胞周期检测点激酶4) Cell cycle checkpoint 细胞周期检查点 1. When cells are exposed to genotoxic stress or when nutrition crisis occurs, cell cycleprogression is usually stopped or slowed down by cell cycle checkpoints to allow for DNA repair or for...
Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy. Mol. Cancer Ther. 5, 1935–1943 (2006). CAS PubMed Google Scholar Carlessi, L. et al. Biochemical and ...
The cell cycle checkpoint kinase Chk1 is another promising molecular target to enhance the cytotoxic effects of radiotherapy and chemotherapy in the treatment of certain cancers. Chk1 plays a major role in mediating S- and G2-arrest in response to DNA-damage. Inhibition of Chk1 enhances the cy...
et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat. Chem. Biol. 6, 359–368 (2010). CAS PubMed PubMed Central Google Scholar Stolz, A. et al. Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular ...
Thecell cycle checkpointkinase Chk1 is another promising molecular target to enhance the cytotoxic effects of radiotherapy and chemotherapy in the treatment of certain cancers. Chk1 plays a major role in mediating S- and G2-arrest in response to DNA-damage. Inhibition of Chk1 enhances the cytoto...
viable and survive for up to two years, indicating that CDK2 is also dispensable for proliferation and survival of most cell types. But CDK2 is essential for completion of prophase I during meiotic cell division in male and female germ cells, an unforeseen role for this cell cycle kinase. ...