Checkpoints in the Cell Cycle:在细胞周期检查点in,细胞,In,CELL,CYCLE,细胞周期,cell,cycle,细胞周期检,Cell 文档格式: .pdf 文档大小: 158.88K 文档页数: 8页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 论文--毕业论文
文档标签: cell cycle checkpoints arresting progress in mitosis GorbskySummaryCellcyclearrestphasecansinglechromosomeattachproperlymitoticspindle.samecellcyclecheckpointmediatesphasearrestwhencellseitherdisrupthyperstabilizespindlemicrotubules.Studyyeastmutantsmicrotubuledisruptorsidentifiedgenesimportantcheckpointpathway.Tworecent...
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17, 615–628 (2003). Article CAS PubMed PubMed Central Google Scholar Shechter, D., Costanzo, V. & Gautier, J. ATR and ATM regulate the timing of DNA replication origin firing. Nature Cell ...
Bioessays News & Reviews in Molecular Cellular & Developmental BiologyDownes C.S. and Wilkins A.S. (1994). Cell cycle checkpoints, DNA repair and DNA replication strategies. Bioessays 16, 75-79.Downes C S,Wilkins A S.Cell Cycle Checkpoints, DNA Repair and DNA Replication Strategies. Bio...
In contrast, a tow level of ppGpp daring bal;mced growth is primarily maintained by SpoT whict~ :tppears to have both ppGpp hydrolytic and synthetic activities 1161. lnteresth~gly, in an E co6 mutant which is apparently devoid of ppGpp, through deletion of both the relA and sp垄,T...
checkpointsdnaintegritycyclecheckpointstructure DNAStructureandIntegrityCheckpointsduringtheCellCycleandTheirRole inDrugTargetingandSensitivityofTumorCellstoAnticancerTreatment AndrzejSkladanowski,* ,† PrzemyslawBozko, ‡ andMichalSabisz † DepartmentofPharmaceuticalTechnologyandBiochemistry,FacultyofChemistry,Gdansk...
Next, we chose to study ATR-CHK1-WEE1 signaling to gain more insight into the impact of cisplatin on cell cycle progression in relation with these well-known cell cycle checkpoint proteins. After cisplatin addition, CHK1 phosphorylation, a target of ATR, gradually increased, while CHK2 ...
The S-phase “checkpoint” halts cells during the DNA synthetic period in response to DNA damage, and is somewhat different from other checkpoints in two ways: First, in the classic paradigm, cell cycle progression is halted at various discrete points in the cycle (e.g., in G1, at the...
In addition, Neoplastic cells_6 widely expressed the highly invasive gene PTTG1, the cell cycle-related genes CCNB1 and CENPF, and the proliferation-related marker genes MKi67 and TOP2A (Fig. 2E). Infinite proliferation, migration, and invasion are unique malignant biological behaviors of tumor...
View PDFHighlights Summary In normal cells, p53 is activated by DNA damage checkpoint kinases to simultaneously control the G1/S and G2/M cell cycle checkpoints through transcriptional induction of p21cip1 and Gadd45α. In p53-mutant tumors, cell cycle checkpoints are rewired, leading to ...