事实上,早在86年前,美国生理学家、“现代睡眠之父”Nathaniel Kleitman便提出了基本休息-活动周期(basic rest-activity cycle,BRAC) 。这种生理唤醒机制不仅仅存在于睡眠期间,清醒时期同样适用。 具体来说,每个周期的总长度大约在80~120分钟;活动90分钟,休息20分钟,为一个周期。 BRAC波动示意图(图片来源:Nathaniel K...
Within this Subject (25) Basic (25) Other Topic Rooms Genetics Cell Biology Cell Origins and Metabolism Proteins and Gene Expression Subcellular Compartments Cell Communication Cell Cycle and Cell Division Scientific Communication Career Planning ...
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease. Nat. Rev. Rheumatol. 16, 496–513 (2020). Article PubMed Google Scholar Crow, Y. J. & Manel, N. Aicardi–Goutières syndrome and the type I interferonopathies. Nat. Rev. Immunol. 15, 429–440 (2015)...
How is the cancer cell cycle different from a normal cell cycle? Provide a rationale for your answer. How is cancer a disease of the cell cycle? Explain. Give an example of an organism that has a sexual life cycle and briefly describe this cycle. Explain how and w...
Most of the cases have the characteristic translocation of chromosome t (11;14) (q13: q32), which leads to excessive activity of the cell cycle regulator, cyclin D1 (CCND1/PRAD-1) gene [6]. CCND1 is a diagnostic feature for MCL because normal B lymphocytes do not express it [7, 8...
Then, lymphocytes are transported to the tumor site to exert an immune response [16, 17, 19, 20, 22, 56,57,58,59], and an internal cancer-immunity cycle may be formed in these tissues. However, the initiation and process of its formation is still unclear. We found by transcriptome ...
Altogether, the findings provided from the frog model and the first findings in mammals substantially improve our basic understanding of this organ-specific adult stem cell development and physiology. They will surely contribute valuable information for regenerative medicine of the digestive tract and for...
This is a contract-based cellular service plan where you’re billed at the end of each month for the services you used during the billing cycle. This includes the base fee for the plan, the cost of any overages, and any international roaming charges, as well as taxes and other fees ...
The network that regulates the mitotic entry of the cell-cycle in eukaryotes also makes a decision before it induces early mitotic processes. Here we show that the switch from inactive to active forms of the mitosis promoting Cyclin Dependent Kinases is driven by a system that is related to ...
Using U2OS-FUCCI cells that mark different phases of cell cycle33, we found that cell death in shATR cells was not dependent on the cell cycle phase (Supplementary Fig. 3b). We found comparable range of 53BP1-GFP foci in ATR-inhibited cells and in control cells; moreover, the presence...