Cell cycle: Simply effectiveDiscusses research being done on the mechanism of Cdc20 phosphorylates for anaphase-promoting complex or cyclosome inhibition by the spindle checkpoint. Reference to a study by Hongtao Yu et al published in a 2004 issue of "Molecular Cell"; Way by which spindle ...
in nucleosome-depleted regions (NDR) ► On a cell-cycle-regulated promoter, NDR ensures reliable, once-per-cycle activation ► In contrast, nucleosomal factor binding sites induce bimodal, “on/off” expression ► NDR limits stochasticity in gene expression and ensures robust cell cycle ...
well as stemness, cytotoxicity and cell cycle properties (Fig.2b–dand Extended Data Fig.5b–f). Fig. 2: Association of surface marker expression with cell type identities, cellular differentiation and biological processes. a, For each surface marker measured in our 97-plex Abseq data, the fr...
mtDNA continuously synthesized throughout the cell cycle, and the DNA polymerase responsible for replicating mtDNA has poor proofreading ability; therefore, mtDNA is prone to mutations and deletions [157]. However, mtDNA sequences have
The association between the cell translocation rate and retrograde flow can be explained by the existence of a molecular clutch [73,64]. The molecular clutch is thought to be composed of vinculin, talin and other adhesion complexes, and determines the extent to which the cytoskeleton and ...
This is a contract-based cellular service plan where you’re billed at the end of each month for the services you used during the billing cycle. This includes the base fee for the plan, the cost of any overages, and any international roaming charges, as well as taxes and other fees ...
For cell cycle analysis, A549 cells (1 × 106/ml) were treated with PBS or HcHAb18-DM1 (10 and 60 μg/ml) added to the medium for 4 h at 37 °C. Treatments were removed and common medium was added for a 24-h incubation at 37 °C. Cells were fixed with 70%...
Furthermore, we used flow cytometry to analyse the cell cycle distribution of the cells in the ApoEVs, H-ApoEVs, and PBS groups. As shown in Fig. 3D, the numbers of cells in the S and G2 phases were significantly greater in the H-ApoEVs and ApoEVs groups than in the PBS group, ...
Genes with zero inflation can potentially help to reveal hidden biological factors such as stage in the cell cycle, activation status of immune cells, or incomplete classification of cell types that vary across the heterogeneous mixture of cells. The model selection procedure implemented in scRATE ...
During cellular differentiation chromosome conformation is intricately remodelled to support the lineage-specific transcriptional programs required for initiating and maintaining lineage identity. When these changes occur in relation to cell cycle, divis