An integrative understanding of nuclear events including transcription in normal and cancer cells requires comprehensive and quantitative measurement of protein dynamics that underlie such events. However, the low abundance of most nuclear proteins hampe
5a–d). While using KEGG annotations of cell cycle and apoptosis genes which were also highly variable in the dataset to estimate growth, an approach described in a previous work18, the cells at the final stage achieve highest potential to divide (Fig. 5e,f and Supplementary Note 2). It ...
KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 2016;44:D457–62. Article CAS Google Scholar Santos A, Wernersson R, Jensen LJ. Cyclebase 3.0: a multi-organism database on cell-cycle regulation and phenotypes. Nucleic Acids Res. 2015;43:D1140–4. ...
inYeastCellCyclePathway ToshiakiKatayamaMinoruKanehisa katayama@kuicr.kyoto-u.ac.jpkanehisa@kuicr.kyoto-u.ac.jp InstituteforChemicalResearch,KyotoUniversity,Gokasho,Uji,Kyoto611-0011, Japan Keywords:cellcycle,pathway,microarray,KEGG 1Introduction
2d. The KEGG enrichment analysis highlighted the remarkable upregulation of genes involved in the cell cycle and DNA replication pathways (Fig. 3a, c). In contrast, genes associated with fatty acid oxidation (FAO) in the peroxisome and the tricarboxylic acid cycle were significantly enriched among...
The serine/threonine kinase PLK family's prominent member, Polo-like kinase 1 (PLK1), has been extensively studied for its critical role in cell cycle progression, encompassing the fundamental aspects of chromosome segregation, centrosome maturation, and cytokinesis. However, the function of PLK1 ...
Yet, another model that was proposed to underlie oscillations in translation during the cell cycle of the yeastSaccharomyces cerevisiaerelies on a global oscillation in the total tRNA pool [39]. Specifically, the expression of a number of tRNA synthetases was found to oscillate during the yeast ce...
这里我们以小鼠为示例,也是常见物种的GSVA分析,结合单细胞的数据!GSVA其实就是对功能富集的量化,然后进行差异分析,寻找感兴趣的通路在样本中的变化。不同于常规的GO、KEGG受差异基因阈值的影响,GSEA受实验分组的影响,GSVA能够对通路量化,看感兴趣通路在多组之间的变化!
l KEGG pathway analysis of p57-expressing NPCs enriched genes (edgeR; p < 0.03, expression top 1000). Full size image We next investigated whether cell cycle inhibition might be sufficient to reprogram embryonic NPCs towards adult NSCs in addition to maintaining the undifferentiated state. We...
S. Aberrant neuronal cell cycle re-entry: the pathological confluence of alzheimer’s disease and brain insulin resistance, and its relation to cancer. J. Alzheimers Dis. 67, 1–11 (2019). Article PubMed PubMed Central Google Scholar González-García, I. et al. mTOR signaling in the ...