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The i-AID system decreased the level of Mcm4-aid protein to about 10% of the original amount at 1 h after auxin addition (Figure 3), suggesting the utility of this system for depletion of the protein within a short period during the cell cycle. Although the i-AID system resulted in ...
美国Flexcell公司专注于细胞组织应力(牵张拉伸应力、三维水凝胶牵张拉伸应力、压应力和流体切应力等)加载刺激培养产品的设计和制造,美国Flexcell细胞应力加载培养与实时观察分析系统,包括:1.1.FX-5000T体外细胞
(QC, Fig.9H), which strongly induced p53 function in RCC as well as in other types of cancer cells [143]. They found that the induction of p53 by these compounds does not involve genotoxic stress but involves the suppression of NF-κB activity [143]. In contrast to agents that target...
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel no
Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a mul
(H+), which are transported to the niche of turmeric cells, are among the most abundant metabolites released by these cells [299,300,301]. The accumulated lactate leads to low pH in the TME or acidification, which limits the activity of immune cells by suppressing the activation of NK ...