块大小是HBase的一个重要配置选项,默认块大小为64k,默认单位是字节,采用这种细粒度,目的是块操作时更加有效加载和缓存数据,对块大小的调整,主要取决于两点: 1. 用户平均读取数据的大小。 理论上讲,如果用户平均读取数据的大小较小,建议将块大小设置较小,这样可以使得内存可以缓存更多block,读性能自然会更好。 相反...
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It is also reported that inhibiting JAK/STAT pathway can block CSC self-renewal [84]. In the breast cancer, expression of a variety of lipid metabolic genes, including carnitine palmitoyltransferase 1B (CPT1B), which encodes the key enzyme for fatty acid b-oxidation (FAO) is also blocked ...
The metabolic shift in CSCs of colorectal cancer is correlated with 5-fluorouracil (5-FU) resistance, and a combination of 5-FU and metformin to block mitochondrial activity has effectively reduced the population of CSCs [319]. In glioblastoma CSCs, combination therapy of 3-bromopyruvate that ...
block nonspecific binding, the tissue sections were pre-incubated with 10% normal goat serum for 30 min. Subsequently, they were incubated overnight at 4 °C with primary antibodies in a humidified chamber. The primary antibodies used to validate mast cells included mouse anti-humanCMA1(AbCam, ...
A FASTA protein sequence database was created by combining two FASTA databases – (i) protein sequences from the human genome reference hg19 and (ii) protein sequences modified by genomic variants - SNVs, short indels and block substitutions. To merge the two FASTA files, both have been conc...
The remaining genes were used to estimate the activity matrix (H) in the target cohort, using a nonnegative least-squares (NNLS) fit of the source NMF gene program (W) matrix on the transformed and normalized expression values of the target dataset. NNLS fit was performed using the Block ...
The local pathologist also selected representative slides and a formalin-fixed tissue block from each patient to submit for regional review and more detailed immunophenotyping. Patients in which the tissue blocks were exhausted or no longer available for study were also acceptable if the slides and ...