Drugs that block proteins involved in immune checkpoints, the pathways that regulate activation of the immune system. In cancer imunotherapy, these drugs (for example, anti-CTLA4, anti-PD1) are used to activate antitumour immunity. Intimal rupture Rupture of the innermost — intimal — layer of...
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Further antigen unmasking was performed using incubation in 96ºC TRS buffer pH 6,1 for 50 min in the case of pAkt(Thr308) and 60 min for both Akt and pAkt(Ser473). Sections were then subjected to exogenous peroxidases quenching in RT (10 min with peroxidase block and 30 min in ...
Here, we show that mutations in the MPER, which block cell-free virus infection, are tolerated in the context of cell-to-cell transmission and that the block to cell-free virus infectivity can be partially reversed by mutations in the CT of gp41. We also observed that an MPER mutation ...
Different phases of synchronized cells were obtained by harvesting cells at different times after release from a thymidine-induced G1 block (Figure 3A and 3B). As shown in Figure 3B (left), the majority of the cell population was in S-phase (80%) at 5 h and proceeded into G2/M phase...
A FASTA protein sequence database was created by combining two FASTA databases – (i) protein sequences from the human genome reference hg19 and (ii) protein sequences modified by genomic variants - SNVs, short indels and block substitutions. To merge the two FASTA files, both have been conc...
Real-time PCR was performed on ExicyclerTM 96 Real-Time Quantitative Thermal Block (Bioneer, Daejeon, South Korea) using cDNA, 2×Taq PCR MasterMix (PC1150, Solarbio Life Sciences, Beijing, China), SYBR green (SR4110, Solarbio) and primers. The primer sequences were shown below: homo HER...