块大小是HBase的一个重要配置选项,默认块大小为64k,默认单位是字节,采用这种细粒度,目的是块操作时更加有效加载和缓存数据,对块大小的调整,主要取决于两点: 1. 用户平均读取数据的大小。 理论上讲,如果用户平均读取数据的大小较小,建议将块大小设置较小,这样可以使得内存可以缓存更多block,读性能自然会更好。 相反...
CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules...
Ubiquitin is a 76-amino acid protein, and as such bears many potential sites for additional post-translational modifications. The key features of ubiquitin are its seven Lys residues, all of which can be ubiquitinated, to give rise to isopeptide-linked ubiquitin chains. An eighth chain type, Me...
together with the four-dimensional one-hot-encoded sequence as input (Fig.2a). The PrismNet architecture uses a convolutional layer, a two-dimensional residual block37and a one-dimensional residual block connected by max pooling to capture sequence ...
CO2is an important component of pH regulatory mechanisms in biological systems. In an aqueous environment, dissolved CO2partially reacts with water to form H2CO3, which dissociates into HCO3−and H+. The balance between H2CO3and HCO3−levels underlies the most important mechanism of maintaining...
Gainor JF, Shaw AT (2013) The new kid on the block: RET in lung cancer. Cancer Discov 3(6):604–606. doi:10.1158/2159-8290.CD-13-0174 Article CAS PubMed Google Scholar Garrett JE, Tamir H, Kifor O, Simin RT, Rogers KV, Mithal A, Gagel RF, Brown EM (1995) Calcitonin-sec...
block nonspecific binding, the tissue sections were pre-incubated with 10% normal goat serum for 30 min. Subsequently, they were incubated overnight at 4 °C with primary antibodies in a humidified chamber. The primary antibodies used to validate mast cells included mouse anti-humanCMA1(AbCam, ...
For example, cell attachment to III1-C is partially inhibited by agents that block β1 integrins or by heparin. Complete inhibition of cell attachment is seen only when integrin blocking agents are combined with heparin. Affinity chromatography revealed the binding of proteins that likely represent ...
Unexpectedly, Akt inhibition did not block Sal’s protective effects in PA-induced cell death, eliminating the Akt pathways as a mediator of Sal’s favorable effects in lipotoxicity of hepatocytes. Other potential candidates for Sal actions are the MAPKs pathways, which are essential in regulating...
Additional file 2:MSOR block oncogenic H-Ras-induced signaling. NIH3T3 cells were transiently transfected with E1, E1-R1 or E1-R3 together with an expression construct encoding H-RasG12V as indicated. Subsequently, plasmids encoding an MMP-1-firefly-luciferase reporter and renilla luciferase were ...