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For decades, it was commonly accepted that the brain is secluded from peripheral immune activity and is self-sufficient for its maintenance and repair. This simplistic perception was based on the presence of resident immune cells, the microglia, and barr
Differential timing of lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study. Development 105, 365–378 (1989). Google Scholar Stewart, C. & Burke, B. Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin...
文章链接: Mapping the developing human immune system across organs 单细胞基因组学研究已经解码了几个人类产前器官的免疫细胞组成,但在理解免疫系统作为一个跨组织的分布式网络方面很有限。本文利用空间转录组学来重建9个产前组织,以重建发育中的人类免疫系统。这揭示了髓系和淋巴细胞亚群晚期获得免疫效应功能,以及单...
LaRusso, N. F., Vo, N. V., Wang, Y., Kelley, E. E., Huard, J., Stromnes, I. M., Robbins, P. D., & Niedernhofer, L. J. (2021). An aged immune system drives senescence and ageing of solid organs.Nature, 594(7861)...
The lymphatic system later develops from the endoderm of pharyngeal pouches, where the thymic anlage differentiates. The lymphocytes that originate here seed all lymphatic organs and retain the ability to divide and thereby form multiple colonies (lymphatic nodules) in the respiratory and digestive ...
Sites within secondarylymphoid organswhere B cells proliferate, differentiate, mutate their antibody genes, and class switch their antibody during immune responses. Marginal zone This is a region at the interface between the red pulp (nonlymphoid) and white pulp (lymphoid) areas of the spleen. It...
文章链接: Mapping the developing human immune system across organs 单细胞基因组学研究已经解码了几个人类产前器官的免疫细胞组成,但在理解免疫系统作为一个跨组织的分布式网络方面很有限。本文利用空间转录组学来重建9个产前组织,以重建发育中的人类免疫系统。这揭示了髓系和淋巴细胞亚群晚期获得免疫效应功能,以及单...
B-cell lymphoma is a type of blood cancer that affects the B lymphocytes of the immune system. They usually arise in the lymph nodes or in other lymphoid tissue, such as the spleen, bone marrow, blood or other organs. B-cell lymphomas are composed of large B lymphoid cells whose nuclear...
Clinical and experimental observations established the gut as a central organ for several IMIDs of extra-intestinal organs and demonstrated disease-relevant communication via the gut–liver, gut–joint and gut–brain axes. Cell trafficking mechanisms along these axes include the induction of pathogenic ...