7. ] Signaling molecules and their receptors 7.2 Nitric oxide crosses the plasma membrane and actives intracellular enzymes directly 7.3 Functions of cell surface receptors 7.4 Signal network system 7.5 Cell signaling and the cytoskeleton 7.6 Cell communication in plants Chapter 8 Nucleus and chromosome...
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Organoids recreate a highly physiologically relevant system that allows researchers to investigate complex, multidimensional questions, such as disease onset, tissue regeneration, and interactions between organs. Light microscopy is an essential approach to study the complex interactions and relations with org...
based on the concept of optimal transport. It can analyse large-scale single-cell data, enabling mapping of the developmental trajectories of individual cells in and across organs. Moscot is scalable to millions of cells, and can track several cell characteristics simultaneously in space and time....
TLSs are distinguished by the presence of a central region consisting of CD20 + B cells, encircled by CD4 + T cells and CD8 + T cells, resembling the lymphoid follicles observed in secondary lymphoid organs (SLOs) [17, 53, 54]. Different DC populations are selectively present...
文章链接: Mapping the developing human immune system across organs 单细胞基因组学研究已经解码了几个人类产前器官的免疫细胞组成,但在理解免疫系统作为一个跨组织的分布式网络方面很有限。本文利用空间转录组学来重建9个产前组织,以重建发育中的人类免疫系统。这揭示了髓系和淋巴细胞亚群晚期获得免疫效应功能,以及单...
Commonalities as well as tissue-specific features of primary and supportive cell types across human organs are beginning to emerge from these human tissue maps. In this Review, we highlight key biological insights obtained from cross-tissue studies into epithelial, fibroblast, vascular and immune ...
their effectiveness in formation of metastases varied between different cell lines androutes of administration. The subcapsular route seems to give the highest rate of successful development of metastases and resulted in extensive metastasis to the lungs and in all peritoneal organs. The potential of or...
Layers of peritoneum that surround abdominal organs. Malate–aspartate shuttle A biochemical system that translocates electrons from the cytosol into the mitochondria for oxidative phosphorylation; the process involves the exchange of malate and aspartate between the two compartments. Glutathione A tripeptide...