[5]Furman D,et al. Chronic inflammation in the etiology of disease across the life span[J].Nat Med.2019,12:1822-1832. DOI: 10.1038/s41591-019-0675-0. [6]Yousefzadeh MJ,et al. An aged immune system drives senescence and ageing of solid organs[J].Nature.2021,594(7861):100-105. D...
For decades, it was commonly accepted that the brain is secluded from peripheral immune activity and is self-sufficient for its maintenance and repair. This simplistic perception was based on the presence of resident immune cells, the microglia, and barr
Clinical and experimental observations established the gut as a central organ for several IMIDs of extra-intestinal organs and demonstrated disease-relevant communication via the gut–liver, gut–joint and gut–brain axes. Cell trafficking mechanisms along these axes include the induction of pathogenic ...
Chronic inflammation in the etiology of disease across the life span[J].Nat Med.2019,12:1822-1832. DOI: 10.1038/s41591-019-0675-0. [6]Yousefzadeh MJ,et al. An aged immune system drives senescence and ageing of solid organs[J].Nature.2021,594(7861):100-105. DOI: 10.1038/s41586-021-...
Although knockout of Pdgfb and Pdgfrβ causes perinatal lethality because of vascular insufficiency due to mural cell hypoplasia (Leveen et al., 1994; Soriano, 1994), the degree of mural cell loss differs between different organs (Hellstrom et al., 1999; Lindahl et al., 1997). For example...
In 1938, Carrel published the book “The culture of organs,” in which he presented the cultivation techniques of whole organs. Carrel started a collaboration with Charles A. Lindbergh in 1930. They worked on the process of organ perfusion, such as whole heart perfusions of cats and kittens....
The cells of an organism are made up of a limited number of ‘cell types’ that are reused in different tissues and combine to form organs and systems. For example macrophages, phagocytic immune cells, are found throughout the body,1 as are connective fibroblast cells.2 However, defining a...
LaRusso, N. F., Vo, N. V., Wang, Y., Kelley, E. E., Huard, J., Stromnes, I. M., Robbins, P. D., & Niedernhofer, L. J. (2021). An aged immune system drives senescence and ageing of solid organs.Nature, 594(7861)...
A vascular network that drains fluid from the extracellular space and traffics this and immune cells to lymphoid organs and the systemic circulation. Adaptive immune cell A T cell or B cell that can acquire and maintain specific knowledge of non-self-pathogens (or self-antigens during disease) ...
Commonalities as well as tissue-specific features of primary and supportive cell types across human organs are beginning to emerge from these human tissue maps. In this Review, we highlight key biological insights obtained from cross-tissue studies into epithelial, fibroblast, vascular and immune ...