In several paediatric reports, ceftriaxone was found to achieve good CSF levels, above the MIC for meningitis pathogens. After single daily dose, CSF concentrations remain greater than 2 mg/ml for the 24 hours following the injection. In all randomized comparisons, ceftriaxone appeared as effective...
250 mg IM as single dose with doxycycline, with or without metronidazole for 14 days Prosthetic Joint Infection 2 g IV q24hr for 2-6 weeks; continue treatment until clinical improvement observed and patient is afebrile for 48-72 hr Meningitis 2 g IV q12hr for 7-14 days Acute Uncomplicated...
The average values of maximum plasma concentration, elimination half-life, plasma clearance and volume of distribution after a 50 mg/kg IV dose and after a 75 mg/kg IV dose in pediatric patients suffering from bacterial meningitis are shown in Table 3. Ceftriaxone penetrated the inflamed meninges...
Prospective comparative trial of ceftriaxone vsconventional therapy for treatment of bacterial meningitis in children. Pediatric Infectious Disease 4: 362–367, 1985 PubMed CAS Google Scholar Bartley SDK, Taylor KM, Rothwell DL. Comparative study of single dose ceftriaxone and triple dose cefuroxime ...
Usual Pediatric Dose for: Bacteremia Joint Infection Osteomyelitis Septicemia Bacterial Infection Urinary Tract Infection Meningitis Otitis Media Skin and Structure Infection Pneumonia Bronchitis Intraabdominal Infection Gonococcal Infection - Uncomplicated Gonococcal Infection - Disseminated Meningococcal Meningitis...
AdultPediatric Dosage Forms & Strengths injectable solution 1g/50mL 2g/50mL powder for injection 250mg 500mg 1g 2g 10g 100g Intra-abdominal Infections Complicated, mild-to-moderate, community acquired: 1-2 g/day IV in single daily dose or divided q12hr for 4-7 days, in combination with me...
Dose: 1 g IM/IV q24h for at least 7 days; Info: may switch to PO regimen to complete course after 24-48h of clinical improvement; 1st-line agent; if chlamydial infection not excluded, give w/ doxycycline, or azithromycin in pregnant pts [meningitis] Dose: 1-2 g IV q12-24h x10-14...
Pediatric Research18,282 (1984)Cite this article 220Accesses Metrics Abstract Thirteen infants (0.4-1.4 yrs) with meningitis were studied. CTX therapy consisted of a 75 mg/kg LD, followed by 50 mg/kg MD every 12 hrs IV over 10 minutes. Simultaneous blood and CSF samples were obtained in ...
meningitis, and respiratory tract infections in older infants and children, along with its unique pharmacokinetic features, ceftriaxone has been used excessively for outpatient management of febrile infants and young children being evaluated for possible systemic bacterial infection. Single-dose therapy was ...
Treatment of disseminated gonococcal infections (e.g., sepsis, arthritis, meningitis) and gonococcal scalp abscesses in neonates. Contraindicated in certain neonates (see Pediatric Use under Cautions). AAP recommends cefotaxime in infants with hyperbilirubinemia....