Pediatric Dosing Author:Alice Jenh Hsu, Pharm.D., BCPS INDICATIONS INDICATIONS INDICATIONS FDA FDA FDA Urinary tract infections Lower respiratory tract infections Skin and skin structure infections Gynecologic infections, includingPID(note: no activity againstC. trachomatis) ...
1) No abnormalities attributable to cefotetan were noted in any examined items such as symptoms, blood pressure, heart rate, electrocardiogram, body temperature, hematology, blood chemistry, COOMBS' test and urinalysis.2) The mean plasma levels of cefotetan 15 min after dosing were 85.2 and 171μ...
Nonevaluability rates were 10 percent for the cefotetan patients and 22 percent for the cefoxitin patients, the majority being due to dosing errors. Demographic characteristics demonstrated 88 percent to be female, 81 percent to be less than 65 years of age, and the average weight to be 165 ...
The maximum urinary cefotetan concentrations occurred during the first 2 hours after dosing by both routes of administration. Cefotetan tautomer was detected in the plasma and urine of all subjects after both routes of administration, but the mean concentrations were only minimal compared to those for...
pharmacokinetic disposition of cefotetan is similar in Caucasian and Japanese subjects and that the long elimination half-life, lack of detectable metabolism and high urinary excretion will result in plasma and urine concentrations in excess of the MIC of sensitive bacteria on a twice daily dosing ...