a semisynthetic fourth-generationcephalosporinantibiotic; used in the treatment of infections of the skin and soft tissues and of the respiratory and urinary tracts. Administered intravenously or intramuscularly as the hydrochloride salt. Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and ...
Cefepime is a fourth-generation cephalosporin with extended antimicrobial coverage. Concerns have been raised about the side effects of cefepime including myoclonus, encephalopathy, and seizures, especially when renal impairment is present. There have been reports of cases of adverse...
Synopsis Cefepime is a 'fourth' generation Cephalosporin that has a broader spectrum of antibacterial activity than the third generation Cephalosporins and is more active in vitro against Gram-positive aerobic bacteria. The fact that cefepime is stable to hydrolysis by many of the common plasmid and...
In addition, Cefepime has higher Gram-negative coverage and more stable resistance to beta-lactamases than third-generation cephalosporins. It penetrates the cell walls of Gram-negative bacteria more rapidly. This is the reason why cefepime covers a wider range of Gram-negative bacteria than third-g...
More AmpB beta lactamase resistant than second and Third Generation Cephalosporins Better activity against Citrobacter and Enterobacter Pseudomonas coverage (similar to Ceftazidime) Although some anaerobic coverage, not active against Bacteroides fragilis Use with Metronidazole for intraabdominal infections III....
Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and... HW Jung,JW Chae,MR Kang,... 被引量: 1发表: 2004年 Open-label, randomised, controlled study to compare the efficacy and safety of cefepime/sulbactam and cefepime in patients with acute ...
Cefepime has increased gram-negative coverage and is more stable against beta-lactamases when compared to third-generation cephalosporins due to a few mechanisms. One such mechanism is that penicillin-binding enzymes have a lower affinity for cefepime. Another difference is that the chemical structure ...
Importantly, cefepime is stable against many of the common plasmid- and chromosome-mediated 尾-lactamases and is a poor inducer of AmpC 尾-lactamases. As a result, it retains activity against Enterobacteriaceae that are resistant to third-generation cephalosporins, such as derepressed mutants of ...
Cefepime (Maxipime, Maxcef, Cepimax, Cepimex, Axepim 1 ), a parenteral fourth-generation cephalosporin, is active against many organisms causative in pneumonia. Cefepime has in vitro activity against Gram-positive organisms including Staphylococcus aureus and penicillin-sensitive, -intermediate and -res...
Cefepime is a semi-synthetic fourth generation cephalosporin with broader Gram-positive and excellent Gram-negative bacterial coverage. Its extended anti-microbial activity and infrequent tendency to develop resistance makes it popular for treatment of infections due to multi-drug resistant organisms. It ...