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Cadherin 17 (CDH17) is a validated biomarker for CRC characterized by its overexpression in tumor tissues (Zheng et al., 2021). CDH17 expression in tissue samples can be reliably detected by immunohistochemistry (IHC), which could potentially provide useful information for malignancy monitoring and...
CDH17 immunostaining was detectable in 2917 (19.5%) of the 14948 analyzable tumors, including 485 (3.2%) with weak, 453 (3.0%) with moderate, and 1979 (13.2%) with strong immunostaining. Overall, 53 (35.3%) of 150 tumor categories showed detectable CDH17 expression and 26 (17.3%) tumor...
(ADCs). These partnerships, aimed at advancing the quantification and prognostic prediction of CDH17 expression in tumor tissue and the surrounding tumor immune microenvironment, are expected to accelerate the development of precise companion diagnostics and effective clinical trials for the treatment of ...
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BI 905711 induced apoptosis in both a cis (same cell) as well as trans (adjacent cell) fashion, translating into significant antitumor activity even in xenograft models with heterogeneous CDH17 expression. In summary, we demonstrate that BI 905711 has potent and selective antitumor activity in CDH...