However, p.S120 is located on the surface of the protein close to the functional calcium sites and in the region of interaction with EC1 domain of another E-cadherin molecule involved in the formation of the intercellular junction. Moreover, p.S120 residue could be involved in posttranslational...
Interestingly, the addition of Cdh1 could promote the interaction between the C2 and HECT domains of WWP2 (Figure 3a). In support of this finding, using GST pull-down assays, we found that Cdh1 could bind directly to either the purified C2 domain of WWP2 or the C2 domain-deleted WWP2 (...
As proposed previously, in the absence of p53, initiation of DNA replication continues and DNA damage accumulates leading to a synthetic lethal interaction between replicative stress and p53 loss44,46. All together, these data suggest a major function for Cdh1 in protecting neural progenitors against...
Differentially expressed genes (DEGs) were identified using four publicly available early-stage BC gene-expression profiles. Protein–protein interaction (PPI) and survival analysis for hub genes was evaluated. The correlation between methylation of genes and prognosis was evaluated using the MethSurv data...
Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancersdoi:10.1158/1538-7445.PANCA20-PO-011Somatic copy number alterations that result in loss of tumor suppressor gene function are important drivers of tumorigenesis. However,...
E-cadherin is a cadherin encoded by the CDH1 gene, essential in normal epithelia. P-cadherin, encoded by the CDH3 gene, exerts a similar function but is mainly present in tumours. E- to P-cadherin switch is a common event in several epithelial tumours. We unveiled a ...
interaction is known to be regulated by the phosphorylation status of Cdh19,24,25,26,27,30. The Chk1 phosphorylation sites on Cdh1 are proximal to the APC/C binding interface of the Cdh1 C-box and KLLR motifs and could potentially influence APC/C–Cdh1 interactions29. To test this idea,...
Fbw7 regulates the stability of various APCCdh1 sub- strates As Cdh1 is the activator of the APC/C E3 ligase, and the interaction between Cdh1 and the APC core subunit was reduced in Fbw7−/− cells (Figure 2G), we suggest that Fbw7 regulates Cdh1 and APCCdh1 substrates at a post-...