SpringerPlus 2012, 1:83 http://www.springerplus.com/content/1/1/83 a SpringerOpen Journal REVIEW Open Access Seventeen years after BRCA1: what is the BRCA mutation status of the breast cancer patients in Africa? – a systematic review Lawal AbdulRazzaq Oluwagbemiga1*, Atoyebi Oluwole1 and...
Stomach cancer:Nearly 1% to 3% of stomach cancers are caused by aCDH1gene mutation. This mutation is an inherited cancer syndrome that can increase the risk of both stomach and lobular breast cancer. Individuals who inherit this gene mutation are at high risk of getting stomach cancer when they...
In Canada, approximately 1 in 200 women develop breast cancer by the age of 40 years, with a cumulative risk of breast cancer before 40 years of 0.61%, which is higher than the global average of 0.44% [2]. Breast cancer in young women (BCYW) is inconsistently defined. Previous studies...
Helicobacter pylori and Epstein–Barr Virus Co-Infection in Gastric Disease: What Is the Correlation with p53 Mutation , Genes Methylation and Microsatellite Instability in a Cohort of Sicilian Population?HELICOBACTER pyloriGASTRIC diseasesEPSTEIN-Barr virus...
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The ability to swiftly and accurately repair DSBs is essential to limit their toxicity, as functional inactivation of genes required to repair DNA breaks results in high cellular toxicity due to delayed or deleterious DSB repair. For instance, mutation of the proximal signaling kinase ATM, which g...
This is now recognized as a variant form of Brooke-Spiegler syndrome (spiradenoma, cylindroma, and trichoepithelioma) caused by germline mutation in the CYLD gene. Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist Szell, "Phenotype-genotype correlation...
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