2A). Functionally, liver cancer cell lines can be classified as either sensitive (Huh7, HepG2, MHCC97H, and SNU398) or resistant (Huh6, PLC/PRF/5, and SNU449) to ATR or CHK1 inhibitors (Fig. 2A). Comparable results were also obtained using IncuCyte short-term cell proliferation ...
TNF-α produced by SEC2 mutant (SAM-3)-activated human T cells induces apoptosis of HepG2 cells. Appl. Microbiol. Biotechnol. 2016, 100, 2677–2684. [Google Scholar] [CrossRef] [PubMed] Wang, L.K.; Feng, Z.X.; Wang, X.W.; Zhang, X.G. EGseq: An R package for identifying ...
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为了验证SCDs是否具有普遍的ER成像能力,选择五种正常细胞(L02,HPAEpiC,NIH/3T3,L929和HUVEC)和五种癌细胞(A549、HeLa,4T1,Hep G2、MC38)分别与SCDs和ER-Red染色。如Fig.7a-b所示,共聚焦图像清楚地表明SCDs和ER-Red在不同细胞系中具有良好的共定位,说明SCDs对活细...
也是在同一年,经过漫长的探索和孵化,吉利德推出了首款抗病毒新药西多福韦(Vistide),用于治疗HIV病人的巨细胞病毒(CMV)视网膜炎。据吉利德的宣传,当时市售的膦甲酸、更昔洛韦需要手术插管给药,但西多福韦仅需静脉注射,这是质的飞跃。 1996年,吉利德的营业收入...
现有的两类抗病毒药物,即核苷(酸)类似物[nucleos(t)ide analogues,NAs]和聚乙二醇干扰素α(pegylated-interferon α,Peg-IFNα),可有效减缓疾病进程,减少终末期肝病的发生,但难以使患者清除血清乙型肝炎表面抗原(hepatitis B surface anti...
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