An in vitro study identified a dual inhibitor of CLK1 and CLK4 that could help treat diseases with aberrant mRNA splicing, such as cancer and influenza infection. Further details on the research, next steps and licensing status are discussed in the article.SciBX: Science-Business eXchange...
细胞分裂周期样激酶 3 (CDC-like kinase 3 (CLK3)) | 重组蛋白 | MedChemExpress (MCE)服务地域:全国 品牌:MedChemExpress (MCE) 产地:美国 厂商性质:生产商 货期:现货 规格:0 近期咨询:0MedChemExpress (MCE) 普通会员 进入商铺 全部产品 产品特点 产品描述 CDC-like kinase 3 (CLK3) 蛋白 MCE 国际...
we show that CDC-like kinase 4 (CLK4) is a critical regulator of cardiomyocyte hypertrophy and heart failure. Knockdown ofClk4leads to pathological cardiomyocyte hypertrophy, while overexpression ofClk4confers resistance to phenylephrine-induced cardiomyocyte hypertrophy. Cardiac-specificClk4-knockout...
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View PDF Download full issue Search ScienceDirect Developmental Cell Volume 14, Issue 3, 11 March 2008, Pages 342-353ArticleNudel Binds Cdc42GAP to Modulate Cdc42 Activity at the Leading Edge of Migrating Cells Author links open overlay panelYidong Shen 1 3, ...
The budding yeast Polo-like kinase Cdc5 is released from the nucleus during anaphase for timely mitotic exit. Cell Cycle. 13:3260-3270.Botchkarev, V.V. Jr.; Rossio, V.; Yoshida, S. The budding yeast Polo-like kinase Cdc5 is released from the nucleus during anaphase for timely mitotic ...
2022年7月8日,同济大学陈义汉、张奇及中国医学科学院心脏节律起源与调控研究团队李丽共同通讯在Nature Communications(IF=18)在线发表题为“CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation”的研究论文,该研究报告了一项CDC样激酶4(CLK4)通过NEXN磷酸化途...
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CLK2 encodes a member of the CLK family of dual specificity protein kinases. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation
The budding yeast Polo-like kinase, Cdc5, has been identified as a key regulator of the meiosis I chromosome segregation pattern. Here we have analysed the role of Cdc5 in the recombination checkpoint and observed that Polo-like kinase is not required for checkpoint activation in yeast meiosis...