The designation “protein kinase C” (PKC) refers to a family of serine/threonine kinases that are involved in cell signaling, leading to proliferation, differentiation, apoptosis and angiogenesis. From: Antiviral Research, 2013 About this pageAdd to MendeleySet alert On this page Definition Chapters...
The serine/threonine kinase Akt, also called protein kinase B (PKB) because of the high homology of its kinase domain with those of protein kinases A and C, is a critical component of the signaling pathway triggered by PI3K. Following activation of PI3K by ligand-stimulated growth factor recep...
and protein kinase rna (pkr)- like er kinase (perk) [ 20 , 21 ]. given the critical role of ire1, perk and atf6 in upr signaling, it is most likely that these receptors would contribute a lot to er stress- induced apoptosis. thus, clarifying the changes in these pathways would be...
Akt(protein kinase B,PKB,蛋白激酶B)抑制剂选择指南 联科生物技术有限公司 杭州市文二路 207 号文欣大厦(310012 ) 免费电话:8008571184 网址: 邮箱:service@ 物流中心:0571 北京:0010 上海:021 广州:020 杭州:0571 苏州:0512 南京:025 厦门:0592-5597797 Akt (protein kinase B,PKB,蛋白激酶 B)抑制剂 选择...
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also called necroptosis). However, how MLKL functions to mediate necroptosi
The humanCLK1gene was first described in 199112. It encodes a 484 amino-acid dual specificity protein kinase with the characteristic signature LAMMER sequence in the C-terminal catalytic domain13. The first 130 amino-acids consist of a regulatory region required for CLK1 to interact with substrat...
protein kinase B EGF: epidermal growth factor ELISA: enzyme-linked immunosorbant assay ER: estrogen receptor GFP: green fluorescent protein Mab: monoclonal antibody PR: progesterone receptor YB-1: Y-box binding protein-1.References Janz M, Harbeck N, Dettmar P, Berger U, Schmidt A,...
蛋白激酶Cβ亚型 1. Co-expression of protein kinase Cβ subspecies in Fos protein immunoreactive neurons in rat superficial dorsal horn during formalin test: an immunocytochemical double staining study; 福尔马林皮下注入引起大鼠脊髓背角表层神经元Fos蛋白和蛋白激酶Cβ亚型的共同表达 :免疫细胞化学双标法...
(b) and pkd1 kinase activity assay was performed. **, p < 0.01 denotes significant difference between ns-sirna-h 2 o 2 and pkcδ-sirna-h 2 o 2 groups (c). full size image the constitutively active catalytic fragment of pkcδ mediates pkd1 activation time course analysis of pkcδ ...
Like mammalian PKCs, TPA-1 has a C-terminal kinase domain and tandem Cys-rich repeats in the N-terminal region, which may represent the phorbol ester-binding region. Just N-terminal to the first Cys-rich repeat is a putative pseudosubstrate site. TPA-1 is homologous to PKC isoforms in ...