Decreased Cdc42 expression is also observed in podocytes of patients with diabetic DN or FSGS. Moreover, we found that podocyte apoptosis was increased in Cdc42 deficiency podocytes in vivo and in vitro. We also further demonstrated that the loss of Cdc42 or its downstream effector Nwasp-...
Diabetes could cause many complications including diabetic nephropathy (DN), diabetic retinopathy and diabetic foot. Furthermore, hyperglycemia can promote tumor progression and increase the risk of malignant cancers. In this review, we summarized the regulation of Cdc42 in insulin secretion and diabetes...
国际上开始重视糖尿病足并发症,一系列足病相关的指南相继问世,如在2011年开始,英国国立卫生保健研究所(The National Institute for Health and Care Excellence,NICE)糖尿病足问题住院管理指南与国际糖尿病足工作组(The International Working Group on th...
Diabetic foot syndrome is a major complication for patients with diabetes mellitus. About 25% of the 6 million patients with diabetes in Germany will suffer from diabetic foot syndrome at some point during the course of disease. Diabetic neuropathy and peripheral vascular disease are the main causat...
Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function[J]. Diabetes Care, 2004, 27:2597-2602. [59] Weng JP, Li Y, Xu W, et al. Effect of intensive insulin therapy on beta-cell function and glycaemic ...
diabetic foot and other neuropathy-related ulcers. The launch was preceded by the publication of a first-of-its-kind, randomized control trial that when compared to standard of care demonstrated up to an 86% reduction in DFU recurrence in people with a previous DFU and diabetic peripheral ...
[4] Burleva E P, Babushkina Y V. Administration of neovasculgen agent for treatment of a patient with neuroischaemic form of diabetic foot syndrome[J]. Angiol Sosud Khir, 2016, 22(2): 47-51. [5] Sanada F, Taniyama Y, Kanbara Y, et al. Gene...
- 《Diabetes Care》 被引量: 73发表: 2011年 Diabetic foot disorders. A clinical practice guideline. For the American College of Foot and Ankle Surgeons and the American College of Foot and Ankle Orth... Foot ulcerations, infections, and Charcot neuropathic osteoarthropathy are three serious ...
Fifty percent of all non-traumatic amputations occur in the diabetic patient. Therisk of a leg amputation is 15 to 40 times greater for a person with diabetes. Each year, six of every thousand diabeticindividuals undergo surgery for an amputation. Objectives: To evaluate the frequency of lower...
Diabetes could cause many complications including diabetic nephropathy (DN), diabetic retinopathy and diabetic foot. Furthermore, hyperglycemia can promote tumor progression and increase the risk of malignant cancers. In this review, we summarized the regulation of Cdc42 in insulin secretion and diabetes...