Methods: THP- 1 cells were differentiated into macrophage-like cells by Me2SO, and then cultured with IFN-纬(500 kU/L) and lipopolysaccharide (LPS) (1 mg/L) with or without triptolide. The surface molecule expre
1.“Self-assembling natural flavonoid nanomedicines for alveolar macrophage reprogramming by restoring mitochondrial function in acute lung injury therapy” 发表于《CHEMICAL ENGINEERING JOURNAL (2025)》,IF:13.300,通过检测小鼠相关细胞中的 CD80 表达,探索肺泡巨噬细胞重编程机制,为急性肺损伤治疗提供新方向。 2...
Raggi F, Pelassa S, Pierobon D et al. Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1. Front Immunol. 2017; 8: 1097.小鼠的巨噬细胞检测，也可以参考此方法，加上F4/80和CD11b作为上级门，圈出总的巨噬细胞。
7A–E): (i) CD80+ and CD86+ APCs vs active CD4+ T cells (β (95% CI) 0.52 (0.04–0.99), P = 0.034; and β (95% CI) 0.12 (− 0.01 to 0.24), P = 0.067, respectively) (Fig. 7A,B), (ii) activated CD4+ T cells vs IL6-producing macrophages (β (95%...
(and CD86) also interacts with CTLA-4 (CD152) expressed on activated T-cells and results in a decrease of the T-cell response. Besides the function as a co-stimulatory molecule for T-cell activation or inhibition, the intrinsic function of CD80 is not known. The CD80 protein is only ...
The expansion of CD80+ and CD86+ T cells but not B cells was associated with increased proliferation in HTLV-1 infection. In vitro treatment with IFN-β but not IFN-α resulted in a pronounced increase of B cell CD86 expression in healthy controls, as well as in patients with ...
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for...
All AML blasts expressed high levels of MHC-I, MHC-II, and CD86 (data not shown) but undetectable levels of CD80 (Fig. 4A). Download: Download high-res image (241KB) Download: Download full-size image Fig. 2. Infection of U937, NB4, and K562 leukemic cell lines by SIN lentiviral ...
Kariv I, Truneh A, Sweet R: Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function. J Immunol 1996: 29-38. Ellis JH, Burden MN, Vinogradov DV, Linge C, Crowe JS: Interactions of CD80 and CD86 with CD28 and CTLA-4. J Immu...
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for...