同时利用聚类得到的2,034个CD8+ T细胞进行cluster聚类来区分终末耗竭T细胞(Cd101、Cd200r2、Cd7、Cd200r1、Il10)和暂时性T细胞(Cx3cr1、Klrg1、Il2ra、Il18rap、S1pr5)(图 4f),再通过已知的CD8 marker来鉴定细胞群(图 2e),最...
immunity compared to effector T cells40. Moreover, memory Tc1 cells are relatively unaffected by the inhibitory effects of regulatory T cells (Tregs) in the tumor microenvironment42. Thus, the frequency of memory Tc1 cells has been proposed to be a potential predictive marker for responsiveness ...
Although several cellular and molecular markers have been described for the identification of CD8+ Tregs (see Table 1, Figure 1, 2 and [20]), there is no single surface marker that is specific for CD8+ Tregs. Table 1 CD8+ Treg markers and mechanisms of action. SubsetNatural/inducedMarkers...
To further study the CD8Tex cells in breast cancer, we collected TCGA cohort to join-analyze the CD8Tex marker genes. The basic clinical information was provided in theSupplementary Table. All of these marker genes indeed have potential value for clinical application, however, the survival associat...
(STING) agonists to promote DC maturation, eliciting inflammatory cytokine production, costimulatory marker expression, and antigen cross-presentation, leading to mobilization and activation of tumor-specific CD8+T cells. This in return resulted in remarkable improvement in the response to anti-PD-1 and...
(f, i) Frequency of FoxP3−CD4+ Tconv cells, FoxP3+CD4+ Treg cells, and CD8+ T cells in tumour tissue. (g, j) Frequency of GzmB expression and Rpl18-specific cells among tumour-infiltrating CTL. (k) Frequencies of activation marker expression among MC38 tumour-infiltrating CTL from ...
Given the different suppressive activity between CD8+CD94+T and CD8+CD94-T cells in ACAID mice, we thinks that CD8+Treg are mainly distributed in CD94+T subpopulation in ACAID. However, it appears that CD94 is not a specific marker for CD8+Treg, as this molecule can be upregulated fo...
CD8+ memory T cells with a high degree of proliferative potential upon reactivation, commonly identified by the expression of lymphoid homing marker CD62L, and that can be abundantly found in the spleen, blood and lymph nodes. CD8+ effector memory T cells (CD8+ TEM cells). CD8+ memory T ...
Canonical cell type marker gene transcript positions are colored to show a (from left to right) P14 T Cell (Xist+Cd8α+Cd3e+) and cDC1 (Clec9a+Xcr1+), P14 T Cell and Endothelial (Pecam1+), P14 T Cell and Fibroblast (Acta2+), P14 T Cell and Lymphatic (Lyve1+), and Cd8α T ...
Neuropilin-1 (Nrp-1) is a marker for murine CD4FoxP3regulatory T (Treg) cells, a subset of human CD4Treg cells, and a population of CD8T cells infiltrating certain solid tumours. However, whether Nrp-1 regulates tumour-specific CD8 T-cell responses is still unclear. Here we show that ...