‘off-the-shelf’ CAR T cells, but the in vitro differentiation of TiPS often yields T cells with suboptimal features. Here we show that the premature expression of the T-cell receptor (TCR) or a constitutively
Identification of an enriched CD4 + CD8alpha ++ CD8beta + T-cell subset among tumor-infiltrating lymphocytes in human renal cell carcinoma. Int. J. Cancer. 1997; 71 :178–182.Van den Hove LE,VanGool SW,VanPopel H,et al.Phenotype cytokine production and cytolytic capacity of fresh (...
CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J. 27, 2839–2850 (2008). CAS PubMed PubMed Central Google Scholar Seitan, V. C. et al. Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments. Genome ...
Consequently, the capacity to try more than one combination of TCR-Alpha/TCR-Beta chains is important because it gives the thymocyte opportunities to “retake” the test for positive selection. If by chance, the cell manages to rearrange an A...
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor ...
CD8+T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8+T cells to gradual deterioration of T cell function, a state called “exhaustion.” Exhausted T cells are characterized by progressive loss of effector functions (cytokine pro...
We observed a marked expansion of the CD161++CD8+ T-cell subset and the emergence of the CD161++CD8αα subset in adulthood (Figure 6B) and a positive correlation is seen between age and frequency of MAIT/CD161++CD8α+ T cells (r = 0.43, P = .0002, data not shown). To address ...
Here we provide direct evidence that precursors of functional CD8αα T cells are positively selected in the thymus in the presence of agonist self-peptides. Like conventional positive selection, this agonist selection process requires functional TCR α-CPM, whereas it is independent of CD8β ...
“TGF-beta” and “cell cycle” pathways. Maintaining normal cell cycle function is essential for the antiviral activity of CD8+T cells. However, CD8+T cell turnover is increased in HIV infected individuals, which reflects a hyper-activated immune status that contributes to the exhaustion and ...
Lipid rafts have been shown to play a role in T cell maturation, activation as well as in the formation of immunological synapses in CD4+ helper and CD8+ cytotoxic T cells. However, the differential expression of lipid raft components between CD4+ and CD8+ T cells is still poorly defined....