in vivo CD8+ T cell depletion Yamada, D. H., et al. (2015). “Suppression of Fcgamma-receptor-mediated antibody effector function during persistent viral infection.” Immunity 42(2): 379-390 in vivo CD8+ T cell depletion Uddin, M. N., et al. (2014). “TNF-alpha-dependent hematopoie...
in vivo CD8+ T cell depletion Evans, E. E., et al. (2015). “Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies.” Cancer Immunol Res 3(6): 689-701. in vivo CD8+ T cell depletion Moir, S., et al. (199...
in vivo CD8+ T cell depletion Yamada, D. H., et al. (2015). “Suppression of Fcgamma-receptor-mediated antibody effector function during persistent viral infection.” Immunity 42(2): 379-390 in vivo CD8+ T cell depletion Uddin, M. N., et al. (2014). “TNF-alpha-dependent hematopoie...
For CD8 T cell depletion, anti-CD8 antibody (BioXCell, BE0061) was administered i.p. (250 μg/dose), starting 7 days before tumor implantation, and continuing every 4 days thereafter. Immunoblot/immunoprecipitation, flow cytometry, and IHC Immunoblots and immunoprecipitation were performed ...
Here, we report the development of a tumor-anchored ɑ4-1BB agonist (ɑ4-1BB-LAIR), which consists of a ɑ4-1BB antibody fused to the collagen-binding protein LAIR. While combination treatment with an antitumor antibody (TA99) shows only modest efficacy, simultaneous depletion of CD4+ T...
BioXcell 产品背景 CD8抗原是一种跨膜糖蛋白,作为T细胞受体的共受体。与TCR一样,CD8与抗原呈递细胞(APC)展示的I类MHC分子结合。CD8主要在细胞毒性T细胞表面表达,但也可在胸腺细胞、自然杀伤细胞和一些树突状细胞亚群上发现。CD8最常见的存在形式是由一个CD8...
In vivo immune cell depletion For macrophage and CD8+ T cell depletion, C57BL/6 mice received intraperitoneal injections of 500 µg anti-CD8α (BioXCell, USA) or anti-CSF1R (BioXCell, USA) every other day for a total of three injections. One week after the final injection, flow cytome...
Despite identifying the YTHDF2-mediated regulation of CD8 T cell persistence, the mechanism by which YTHDF2 promotes CD8 T cell polyfunctionality remains to be addressed. Interestingly, YTHDF2 depletion was thought to mainly stabilize its target genes, but RNA profiling revealed a comparable number...
Depletion of CD8+ T cells was achieved by intraperitoneal (i.p.) injection of 200 µg anti-CD8 (116-13.1, BE0118, BioXCELL) or IgG2a (C1.18.4, BE0085, BioXCELL) isotype control at D4 and D0 relative to tumor cell injection for primary tumor immunity experiments. To deplete CD8+...
CD8+ T-cell depletion One-month-old C57Bl/6 or 129/S6 Pkd1RC/RC mice were treated twice a week for 8 weeks by i.p. injection with 10 mg/kg anti-CD8+ depleting antibody or 10 mg/kg IgG2a control (BioXCell, West Lebanon, NH). After 8 weeks of treatment, the animals were killed...