CD74在多种肿瘤细胞中高表达，例如，乳腺癌，淋巴瘤，多发性骨髓瘤，非小细胞肺癌，慢性淋巴细胞白血病等疾病。在非小细胞肺癌中，CD74和MIF通过调节HIF-1α/MIF/CD74轴的活性，影响肿瘤微环境中的免疫细胞极化和肿瘤细胞的生长。通过靶向抑制MIF/CD74信号通路，可以减少AKT的磷酸化，从而抑制肿瘤的进展，并且通过...
因此,本研究旨在探讨CD74在人肺腺癌发生发展中的作用以及MIF-CD74在肺腺癌细胞体外增殖和迁移中的作用。利用氨基甲酸乙酯诱导的IDLA小鼠模型,我们探索了由人免疫球蛋白G1的Fc部分连接的可溶性肿瘤坏死因子受体组成的重组融合蛋白(sTNFR:Fc)...
CD74macrophage migration inhibitory factor (MIF)macrophage migration inhibitory factor receptorMacrophage migration inhibitory factor (MIF) is a pleiotropic immunoregulatory cytokine whose effects on arresting ‘random’ immune cell movement was already recognized decades ago. MIF is quasi-constitutively ...
内容提示: 中华临床医师杂志 ( 电子版 )2017 年 10 月第 11 卷第 19 期 Chin J Clinicians(Electronic Edition), October 1, 2017, Vol.11, No.19 ·2289·• 综述 •CD74 及 MIF 表达对子痫前期巨噬细胞 - 胎盘滋养层 相互作用的影响【摘要】 子痫前期是一种较为严重的妊娠期并发症,临床上一般...
利用酵母双杂交系统鉴定 MIF 与CD74 胞外片段间的相互作用
13.本发明中,通过将mif及其受体cd74制备调控细胞功能和分裂增殖药物,能够通过调控视网膜色素上皮细胞纤毛生成和功能,进而调控该细胞的生理功能,同时,作为细胞自身产生的内源性生物活性因子,mif调控细胞分裂增殖具有较强的调控能力,利于治疗给药部位的异常的生理功能和分裂增殖。
(Tel:86- 21- 31161821,E- mail:xiazhaofan@163畅com)伍国胜, 孙瑜, 李磊, 夏照帆第二军医大学附属长海医院烧伤科 上海市, 200433【摘要】 CD74 是一种非多态性Ⅱ型跨膜糖蛋白, 2003 年被发现作为巨噬细胞移动抑制因子 (MIF) 的高亲和力膜受体, 参与 MIF 介导的多种信号通路, 与炎性疾病、 自身免疫...
However, the contribution of MIF or MIF-2 to these actions of MIF receptors has not been explored. The safety and efficacy of strategies targeting MIF, CD74, CD44 and CXCR4 are under study in humans. 展开 关键词: Kidney CD74 CXCR2 CXCR4 Macrophage inhibitory factor ...
In T cells, MIF-mediated activation of the JNK pathway led to upregulated gene expression of the inflammatory chemokine CXCL8. Activation of JNK signalling by MIF involved the upstream kinases PI3K and SRC and was found to be dependent on CXCR4 and CD74. Together, these data show that the...
CD74, the cell-surface form of the MHC class II invariant chain, is a key inflammatory factor that is involved in various immune-mediated diseases as part of the macrophage migration inhibitory factor (MIF) binding complex. However, little is known about the natural regulators of CD74 in this...