Lastly, in a cohort of 30 COVID-19 patients, CD74 surface expression was found to be significantly upregulated on CD4 + and CD8 + T cells in patients with severe compared to patients with only mild disease course. Together, our study characterizes the MIF receptor network in the course of...
intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. 仅用于科研。不用于诊断过程。未经明确授权不得转售。 相关产品 免疫组织化学 Secondary Antibodies 同型对照 IHC封片剂...
CD74 is ectopically expressed in many tumors and can regulate tumor immunity. However, there are many gaps in the study of the prognostic value of CD74 expression and immune infiltration in hepatocellular carcinoma (HCC). An online tumor database was sea
2016). CD74-positive macrophages are associated with the infiltration of CD8+ cytotoxic T lymphocytes (CTLs) in HCC (Xiao et al. 2022). In addition to its effect on immune cells, the inhibition or knockout of CD74 can significantly inhibit the proliferation and invasion of tumor cells in ...
intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. 仅用于科研。不用于诊断过程。未经明确授权不得转售。 How to use the Panel Builder Watch the video to learn how to use the Invitrogen Flow Cytometry Panel ...
Mesenchymal stromal cells (MSCs) possess multipotent characteristics and exhibit regenerative and immunomodulatory functions [8]. Notably, in recent years, MSC-based therapy has demonstrated promising efficacy in various cardiovascular ailments. Numerous studies have substantiated the inhibitory effects of MSCs...
The transfected cells were lysed in the Hepes-Triton buffer (20 mM Hepes/NaOH pH 7.4, 1 mM EDTA, 150 mM NaCl, 0.5% Triton-X 100) on ice. The lysates were cleared by spinning at 20,000 g for 10 min. To precipitate the immune complex, the cleared lysates were mixed with FLAG beads...
Statistical analysis was performed using paired and non-parametric Wilcoxon t-test. *p < 0.05. 2.5. MPO-oxMIF interacts with CD74 in cell-based assays We initiated in vitro studies of the oxMIF-CD74 interaction using HT29 colon carcinoma cells as a model for epithelial cells, which are ...
Methods: Migration inhibitory factor, CD74, and calretinin immunoreactivity were investigated in a tissue microarray of 352 patients diagnosed with MPM. Protein expression intensities were semiquantitatively scored in the tumour cells and in the peritumoral stroma. Markers were matched with OS, age, ...
T, and dendritic cell responses [8,9]. CD74 also regulates the functions of non-immune and non-tumor cells [8,10]. Elevated CD74 expression is found in renal tubular cells in some forms of chronic kidney disease, and in glomerular podocytes and parietal cells in human metabolic nephropath...