AIH患者肝内IL-15和TGF-β表达水平显著升高,且肝细胞广泛表达CD103配体- E-钙黏蛋白(E-cadherin),这些因素可能有助于CD8+ TRM细胞的分化和驻留。经过免疫治疗后,AIH患者肝内CD8+ TRM细胞数量显著下降。糖皮质激素可以通过直接下调CD8+ TRM细胞Blimp1的表达,从而抑制CD8+ TRM细胞的体外扩增。 该研究证实了CD69+...
3.4.1CD69 and CD103 According to recent studies,CD69is considered to play a key function in retaining TRM cells in tissues whereas CD103 expressed by TRM cells interact with E-cadherin on the epithelial cells in order to promote resident phenotype in TRMT cells[28,73,74]. Recent studies ...
and the functioning transcription factors were predicted using the UCSC and JASPAR databases.We found that different CD8 + TRM subsets existed in CRC tumor tissues, which were identified as CD69 CD103 CD8 + TRM, CD69 + CD103 CD8 + TRM (SP CD8 + TRM), and CD69 + CD103 + CD8 + TRM...
CD8+TRM 样细胞的作用:对术后样本进行 RNA 测序和免疫浸润分析,发现 nICT 组 pCR 患者的 CD8+T 细胞、中性粒细胞和细胞毒性 T 细胞(Tc)浸润显著增加,且 nICT 组中 CD69 基因及一些 T 细胞共抑制分子表达升高。通过对 TCGA 泛癌数据集的分析,发现 CD69 高表达与更好的 DFS 相关(P<0.001),而 CD103 未...
Wu et al. Cell Communication and Signaling (2024) 22:608 https://doi.org/10.1186/s12964-024-01990-3 Cell Communication and Signaling RESEARCH Open Access CD69+CD103+CD8+ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer Zi-...
Functions of human liver CD69+CD103-CD8+ T cells depend on HIF-2α activity in healthy and pathologic livers Journal of Hepatology Volume 72, Issue 6, June 2020, Pages 1170-1181 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor academic ...
Although CD103- cells were weaker effectors on a per cell basis than CD103+ cells following T-cell receptor or interleukin-15 stimulation, they remained the major CD69+CD8+ effector population in the liver, surviving with less cell death. HIF-2α inhibitor suppressed the effector functions and...
Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response. This study explored the impact of NLRP3 inflammasome activity on the regul
and the functioning transcription factors were predicted using the UCSC and JASPAR databases.We found that different CD8 + TRM subsets existed in CRC tumor tissues, which were identified as CD69 CD103 CD8 + TRM, CD69 + CD103 CD8 + TRM (SP CD8 + TRM), and CD69 + CD103 + CD8 + TRM...
Compared to healthy controls, the absolute number of CD8+ T cells in the intestinal tissues of aGVHD patients was significantly increased(Figure D), while the absolute number and proportion of CD8+CD69+CD103+ TRM cells were significantly decreased (P<0.0001)(Figure E),. Furthermore, patients ...