该CD68 Monoclonal Antibody. CD68 is a highly glycosylated transmembrane protein, which is the most widely used macrophage marker. CD68 is expressed in Kupffer cells, normal lymphoid cells, mast cells and microglia. In tumor tissue, CD68 is expressed in the epithelial cells of fibrous tissue tumors...
Although the function of CD68 has yet to be established, it has often been used as an immunohistochemistry (IHC) marker of inflammation and for granular cell tumors (GCTs). CD68+ tumor associated macrophages (TAMs) has been suggested to be a predictive marker for poor cancer prognosis, but ...
Macrophage Marker Specificity This CD68/SR-D1 Antibody (ED1) recognizes a single chain glycoprotein of 110 kDa that is expressed predominantly on the lysosomal membrane of myeloid cells. Weak cell surface expression also occurs. The antigen is expressed by the majority of tissue macrophages and weak...
Although the function of CD68 has yet to be established, it has often been used as an immunohistochemistry (IHC) marker of inflammation and for granular cell tumors (GCTs). CD68+ tumor associated macrophages (TAMs) has been suggested to be a predictive marker for poor cancer prognosis, but ...
CD15, the X hapten or Lewis X antigen, can be identified with the LeuM1 antibody. Originally noted as a monocyte/myeloid cell marker, it was recognized as a marker for the Reed-Sternberg cells of classical Hodgkin lymphoma. It is negative in most non-Hodgkin lymphomas, with the exception ...
CD68 is considered a pan macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. ...
BackgroundCD68 is a highly glycosylated transmembrane protein, which is the most widely used macrophage marker. CD68 is expressed in Kupffer cells, normal lymphoid cells, mast cells and microglia. In tumor tissue, CD68 is expressed in the epithelial cells of fibrous tissue tumors, some epithelial ...
CD68 tumor expression and a genetic marker (proteasome subunit-β type- 1 (PSMB1) PA11A G allele) for a longer progression-free survival of follicular lymphoma patients treated with bortezomib (proteasome inhibitor) and rituximab (anti- CD20 monoclonal antibody) vs treatment with rituximab alone....
CD68 plays a critical role in promoting phagocytosis; however, the function of CD68 in tumor immunity and prognosis remains unknown. We analyzed CD68 expression among 33 tumor and normal tissues from The Cancer Genome Atlas and Genotype-Tissue Expression
For the negative controls, the primary antibody was eliminated and replaced with PBS. For the quantitative study, stained cells were first counted in three consecutive microscopic fields (×240) and then summed. The mean value was calculated. Student's t-test was used to compare the means ...