该CD68 Monoclonal Antibody. CD68 is a highly glycosylated transmembrane protein, which is the most widely used macrophage marker. CD68 is expressed in Kupffer cells, normal lymphoid cells, mast cells and microglia. In tumor tissue, CD68 is expressed in the epithelial cells of fibrous tissue tumors...
CD15, the X hapten or Lewis X antigen, can be identified with the LeuM1 antibody. Originally noted as a monocyte/myeloid cell marker, it was recognized as a marker for the Reed-Sternberg cells of classical Hodgkin lymphoma. It is negative in most non-Hodgkin lymphomas, with the exception ...
Marker Macrophage Marker Specificity This CD68/SR-D1 Antibody (ED1) recognizes a single chain glycoprotein of 110 kDa that is expressed predominantly on the lysosomal membrane of myeloid cells. Weak cell surface expression also occurs. The antigen is expressed by the majority of tissue macrophages ...
CD68 tumor expression and a genetic marker (proteasome subunit-β type- 1 (PSMB1) PA11A G allele) for a longer progression-free survival of follicular lymphoma patients treated with bortezomib (proteasome inhibitor) and rituximab (anti- CD20 monoclonal antibody) vs treatment with rituximab alone....
Rat anti Mouse CD68 antibody, clone FA-11 recognizes mouse macrosialin, a heavily glycosylated transmembrane protein and murine homolog of human CD68, classified as a unique scavenger receptor (ScR) f…
CD68+ tumor associated macrophages (TAMs) has been suggested to be a predictive marker for poor cancer prognosis, but a meta-analysis showed the presence of CD68 is not correlated with survival (2). In addition, a role in hepatic malaria infection has been reported based on the finding that...
Although the function of CD68 has yet to be established, it has often been used as an immunohistochemistry (IHC) marker of inflammation and for granular cell tumors (GCTs). CD68+ tumor associated macrophages (TAMs) has been suggested to be a predictive marker for poor cancer prognosis, but ...
end-stage human disease: hippocampus and motor cortex, respectively. Sections were immunohistochemically labelled with a two-round multiplexed antibody panel against; microglial functional markers (L-ferritin, HLA-DR, CD74, CD68, and Iba1), a neuronal marker, an astrocyte marker, and pathological ...
CD68 plays a critical role in promoting phagocytosis; however, the function of CD68 in tumor immunity and prognosis remains unknown. We analyzed CD68 expression among 33 tumor and normal tissues from The Cancer Genome Atlas and Genotype-Tissue Expression
Kuffer cells, germinal center, splenic macrophages, and granulocyte precursors are a few examples of many tissue macrophages that recognize epitopes when tagged with the pan-macrophages marker CD68. CD163, a hemoglobin scavenger receptor, was initially identified while looking for specific markers of ...