根据细胞表面CD56的密度,将NK细胞分为 CD56bright和CD56dim 两者类型,它们具有不同的表型特征。CD56bright NK细胞具有产生丰富细胞因子的能力,而CD56dim NK细胞具有更强的细胞毒性,表达更多的免疫球蛋白样受体和FcγRIII (Fcγ受体III,又称CD16)。 激活性受体和抑制性受体均在NK细胞表面表达,有助于NK细胞执行功能。
Response of CD56dim and CD56bright NK cells to Interleukin 21Wilk, EWendt, KBuyny, SSchmidt, R EJacobs, R
non-neurodegenerative and neurodegenerative diseases. We describe how NK cells can migrate into the CNS, while focusing on the differences between CD56brightand CD56dimNK cells, and question the potential immunoregulatory role of CD56brightNK cells. Accordingly, we also describe how the current therapie...
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Human NK cells are divided into CD56(bright)CD16(-) cells and CD56(dim)CD16(+) cells. We tested the hypothesis that CD56(bright) NK cells can differentiate... A Chan,DL Hong,A Atzberger,... - 《Journal of Immunology》 被引量: 539发表: 2007年 Differential expression of SHIP1 in CD...
This phenotypic classification correlates with functional activity as CD56brightNK cells are the major cytokine producing subset whereas CD56dimNK cells exhibit greater cytotoxic activity. Previous studies have revealed a reduction in total NK cell numbers in association with ageing and this study sought ...
Interestingly, IL-7 and IL-21 stimulated degranulation by CD56bright NK cells but not by CD56dim NK cells. NK cell killing of activated CD4+ T cells was suppressed by HLA-E on CD4+ T cells, as blocking the interaction between HLA-E and the inhibitory CD94/NKG2A NK cell receptor ...
FTY720-P inhibited sphingosine 1-phosphate-directed migration of CD56(bright) and CD56(dim) NK cells subsets from untreated healthy donors. IL-12- and IL-15-stimulated NK cells from MS-FTY patients displayed similar capacity to produce IFN-gamma, TNF, IL-10, and MIP-1alpha cytokines/...
CD56 brightNK 细胞虽然杀伤能力较低,但细胞因子分泌能力较强,具有免疫调节功能,在一定条件下 CD56 bright NK 细胞可以分化成为 CD56 dim NK 细胞 [5] 。相当多的 HIV感染者同时合并 HCV 感染,肝相关疾病导致的病死率大大增加。因此,HIV/HCV 共感染日益引起国内外学者的重视。在共感染患者中,NK 细胞的数量和...
NK cells are cytotoxic lymphocytes of innate immunity composed of: cytotoxic CD56dim and immunoregulatory CD56bright cells. The study aimed to analyze the expression of cellular protective proteins: sirtuin 1 (SIRT1), heat shock protein 70 (HSP70) and ma