根据细胞表面CD56的密度,将NK细胞分为 CD56bright和CD56dim 两者类型,它们具有不同的表型特征。CD56bright NK细胞具有产生丰富细胞因子的能力,而CD56dim NK细胞具有更强的细胞毒性,表达更多的免疫球蛋白样受体和FcγRIII (Fcγ受体III,又称CD16)。 激活性受体和抑制性受体均在NK细胞表面表达,有助于NK细胞执行功能。
In response to IL-15, we observed selective activation of the PI3K/Akt/mTOR (4.2 fold increase CD56bright NK cells, 1.2 CD56dim NK cells, p<0.001) and Ras/Raf/MEK/ERK (1.9 fold increase CD56bright NK cells, 1.2 CD56dim NK cells, p<0.001) pathways in CD56bright NK cells. The Jak/...
non-neurodegenerative and neurodegenerative diseases. We describe how NK cells can migrate into the CNS, while focusing on the differences between CD56brightand CD56dimNK cells, and question the potential immunoregulatory role of CD56brightNK cells. Accordingly, we also describe how the current therapie...
Differential alteration of CD56bright and CD56dim natural killer cells in frequency, phenotype, and cytokine response in chronic hepatitis C virus infection BackgroundNatural killer (NK) cells play an important role in immune responses to virus infection. The cell population consists of CD56 (dim-sub...
In contrast to CD56bright NK cells CD56dim cells express killer cell immunoglobulin (Ig)-like receptors (KIR) such as CD158a, CD158b, and NKB1. However, c-type lectin-like receptors (KLR) CD94/NKG2 and CD161 are present on both subsets. The ability to form conjugates with susceptible ...
脐血中CD56~(bright)CD16~(dim) /~-NK细胞亚群的检测 下载积分: 2990 内容提示: 两两比较均存在统计学差异,在内生肌酐清除率尚处于正常范围的 A组,Scy-c 、尿尿 β2-MG 的升高程度更加明显,说明 Scy-c、CRP 、尿β2-MG 对早期肾损伤的灵敏度要优于内生肌酐清除率,与国内一些研究观点相符 [8-9] 。
Transcriptome analysis of a small patient cohort of CD56bright compared to CD56dim NK cells found the NKreg cells to also overexpress Granzyme K, IL-7R, GPR183, RANK, GM-CSFR, TCF7, and IL23A. Further analysis of this CD56bright NKreg population found a subpopulation that overexpressed IRF1...
NK cells are cytotoxic lymphocytes of innate immunity composed of: cytotoxic CD56dim and immunoregulatory CD56bright cells. The study aimed to analyze the expression of cellular protective proteins: sirtuin 1 (SIRT1), heat shock protein 70 (HSP70) and ma
Natural killer (NK) cells are innate lymphoid cells that mediate anti-tumor responses via cytotoxicity and effector cytokine production. Human NK cells are divided into two subsets based on relative expression of CD56 (CD56bright and CD56dim) that classically participate in distinct functions. Cytotoxi...
Although it was originally suggested that CD56 bright NK cells represent the precursors of the CD56 dim subpopulation, recent cumulative data indicate that CD56 bright and CD56 dim NK cells are phenotypically, functionally, and developmentally different NK cell subsets. In this study, the analysis of...