The poor cytolyticcapacity of CD56bright NK cells can be explained by weak ability in forming conjugates with target cells and low contents of perforin and granzyme A in their granules. 展开 关键词: CD56bright CD56dim NK cell KIR KLR DOI: 10.1002/1521-4141(2001010)31:10<...
Transcriptome analysis of a small patient cohort of CD56bright compared to CD56dim NK cells found the NKreg cells to also overexpress Granzyme K, IL-7R, GPR183, RANK, GM-CSFR, TCF7, and IL23A. Further analysis of this CD56bright NKreg population found a subpopulation that overexpressed IRF1...
The PB vs. CB CD56 bright had significant increased expression of KIR2DL2 (20.31 + 2.27 vs. 9.43 + 0.82, p 2 fold between CB and PB CD56 dim NK cells. The functional categories of differentially expressed proteins were binding (46%), catalytic (17%), signaling (15%), transcription (...
Among NK cells, CD56bright CD16neg (cytokine-producing) NK cells are less cytotoxic and produce more cytokines, whereas CD56dim CD16+ (cytotoxic) NK cells are more cytotoxic and produce fewer cytokines (5). A highly dysfunctional population of NK cells (CD56neg CD16+) has been described in...
to the frequency of Siglec-7~+CD56~(dim)NK cells(r=-0.472,P0.01).Conclusion The function of Siglec-7~+NK cells is higher than the negative ones but impaired during HIV infection.And the frequency of Siglec-7~+CD56~(dim)NK cells is negatively correlated to the expression of FAS(CD95)...
NK cells are cytotoxic lymphocytes of innate immunity composed of: cytotoxic CD56dim and immunoregulatory CD56bright cells. The study aimed to analyze the expression of cellular protective proteins: sirtuin 1 (SIRT1), heat shock protein 70 (HSP70) and ma
In contrast to CD56bright NK cells CD56dim cells express killer cell immunoglobulin (Ig)-like receptors (KIR) such as CD158a, CD158b, and NKB1. However, c-type lectin-like receptors (KLR) CD94/NKG2 and CD161 are present on both subsets. The ability to form conjugates with susceptible ...
CD56bright NK cells. Last but not least, granules of CD56dim cells contain about tenfold more perforin and granzyme A enabling potentially more effective cytolysis compared to CD56bright NK cells. On the other hand, CD56bright NK cells are superior in producing the proinflammatory cytokines IFN...
Altogether, CD56(bright) NK cells postallogeneic HSCT exhibit peculiar phenotypic and functional properties. Functional interactions between this subset and T cells may be important in shaping the immune response after HSCT. 展开 关键词: Adolescent Adult Antigens, CD56 Cell Differentiation Cell ...
(B) Representative histogram analysis of the CD56dim and CD56bright populations before (left panel) and after (right panel) expansion Throughout the culture period, fluorescence intensity of the CD56+ population became increasingly bright (Fig. 2B). Whereas on day 0, 44.0% ± 21.0% of the ...