Russell S. CD46: a complement regulator and pathogen receptor that mediates links between innate and acquired immune function. Tissue An- tigens 2004;64:111-118.Russell S (2004) CD46: a complement regulator and pathogen receptor that mediates links between innate and acquired immune function. ...
The function of CD46 during infection extends beyond its expression on the cell surface and importantly, CD46 expression alone does not confer dependency of virus entry. Fibroblast cell lines (MRC5 and HFF-1) express CD46 but do not show inhibition of infection when CD46 is targeted with mAb...
The function of CD46 in T cells was ascribed first as a co-receptor for CD3, similar to CD28, in causing cell proliferation and lowering of thresholds for TCR signalling (Astier et al., 2000). Simultaneous engagement of CD3 and CD46 using immobilized monoclonal antibodies result in increased...
We establish herein that cell contact-mediated nTreg regulatory function is inhibited by inflammation, especially in the presence of the complement C3b receptor (CD46). Instead, as with other T-cell subsets, the latter inflammatory conditions of stimulation skew nTreg differentiation to Tr1 cells ...
Routine liver function tests capture information about the metabolic and inflammatory condition of the liver, but we lack sensitive biomarkers of early hepatocyte stress. In humans, soluble CD46 (sCD46) levels in blood were recently identified as an accurate biomarker of hepatic steatosis. Here, we...
(CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of...
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In search for novel candidate genes implicated in thyroid function, we performed ... P Patrizia,M Federica,B Francesca,... - 《Endocrinology》 被引量: 33发表: 2012年 Jagged1 (JAG1): Structure, expression, and disease associations Jagged1 (JAG1) is one of the 5 cell surface ligands that...
Since the discovery of CD46 as a membrane complement regulator more than 30 years ago, new knowledge has emerged not only about its structure and function as a complement regulator, but also its key interactions as a driver of cellular metabolism and component of the intracellular complement syste...
Flow cytometric assessment of LDL ligand function for detection of heterozygous familial defective apolipoprotein B-100[J]. Clin Chem,2000, 46(2):224-233. [14] Zhou F,Zhou Y,Yang M,et al. Optimized multiparametric flow cytometric analysis of circulating endothelial cells and their subpopulations ...