CX3CR1、CCR2进行了分析,小胶质细胞表达CX3CR1而不表达CCR2标记,Tem119是小胶质细胞的特异性标志物,故很明显,CD11b+CD45med群体是小胶质细胞,而MDM则恰好呈相反的表达模式,所以CD
In the present study, the expression of CD45 on microglia of 42 dogs was examined ex vivo by means of flow cytometry. The dogs were classified in two groups according to the histopathological diagnosis in the CNS. All dogs without changes in the CNS (group I; n = 22) only showed low ...
Here we have examined human bone marrow (hBM) in an attempt to identify novel cell sources for generating microglia-like cells to use in cell-based therapies and in vitro modeling. We demonstrate that hBM stroma harbors a progenitor cell that we name stromal microglial progenitor (STR-MP). ...
Antibodies to CD4, CD8, CD45, and CD11b were used to identify infiltrating T cells (CD4+ and CD8+), monocytes/macrophages (CD45highCD11b+), and resident CNS microglia (CD45lowCD11b+). Data are expressed as percent of CD45+-gated cell population and are representative of at least ...
Regulation of microglia by CD4 � and CD8 � T cells: selective analysis in CD45-congenic normal and Toxoplasma gondii-infected bone marrow chimeras - Schlüter, Meyer, et al. () Citation Context ...(clone RB6-8C5), anti-CD11b-FITC (clone M1/70), and anti-CD45-CyChrome (clone ...
CD11b(+)CD45(+)Brain tumorGR1MDSCGlioblastoma multiforme is characterized by high accumulation of microglia/macrophages. The function of these tumor-infiltrating myeloid cells is not sufficiently elucidated. Therefore, a better understanding of the precise immune cell composition and function in brain ...
CD11b but not CD11c or CD45 immunoreactive microglia significantly activated in the hippocampus of Ad-VIP injected mice.Min SongJiaxiang XiongYanyan WangJun TangBo ZhangYun Bai
Regulation of microglia by CD4+ and CD8+ T cells: selective analysis in CD45-congenic normal and Toxoplasma gondii-infected bone marrow chimeras. Brain Pathol 2001; 11 44-55.Schluter, D., T. Meyer, A. Strack, S. Reiter, M. Kretschmar, C.D. Wiestler, H. Hof, and M. Deckert. 2001...
In the isolated brain immune cells, CD11b+ cells were further distinguished by CD45Hi and CD45Low subsets. The extent of MM trafficking was determined by an intravenous infusion of control GFP+ splenocytes into the stroked WT and CD36KOMM mice 1d prior to sacrifice and MM subset analyses...