In this review, we look back on the discovery of cancer stem cells and the contribution of the findings in blood cancer to a parallel discovery in solid cancers. We focus on CD44 as a stem cell marker, both in blood cancers and in several types of solid cancers, particularly of the...
Orian-Rousseau, "CD44: More than a mere stem cell marker," International Journal of Biochemistry and Cell Biology, vol. 81, pp. 166-173, 2016.Morath, I., Hartmann, T. N. and Orian-Rousseau, V. (2016) CD44: more than a mere stem cell marker. Int. J. Biochem. Cell Biol. 81,...
参考文献: CD44 splice isoform switching determines breast cancer stem cell state, DOI: 10.1101/gad.319889.118 ——本期完—— 我们(医世象,微信ID:medhealife) 致力于癌症、慢病、妇幼等领域的科研成果报道,以及科普知识的传播; 关...
HA and OPN are highly abundant in the leukemic stem cell niche and in solid tumors of various cancer types, where they contribute to the maintenance of the stemness of malignant cells. CD44 has consequently been recognized as a cancer stem cell marker in several types of cancers, which has ...
various human cells, including embryonic stem cells, differentiated cells, and cancer cells. During transcription, different alternative splicing generates two types of CD44 variants, known as standard type (CD44s) and CD44 variant type (CD44v). Recognized as a hallmark of tumor stem ...
Prowse AB,Chong F ,Gray PP ,et a1.Stem cell integrins:impli— cations fo r ex—vivo culture and cellular therapies [ J ] .Stem Cell R es,20 11 ,6 ( 1) :1-12. [ 16 ] Marhaba R,Freyschmidt-Paul P,Zoller M.In vivo CD44- CD49d ...
CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types including cancer stem cells and frequently shows alternative spliced variants that are thought to play a role in cancer development and progression. Hyaluronan, the mai
The stem cell niche provides a regulatory microenvironment for cells as diverse as totipotent embryonic stem cells to cancer stem cells (CSCs) which exhibit stem cell-like characteristics and have the capability of regenerating the bulk of tumor cells while maintaining self-renewal potential. The tran...
内皮细胞是血管的重要组成部分,在循环血液和组织之间的界面上发挥作用,在维持身体的生理功能方面发挥着许多重要作用,血管内皮细胞(VEC)衰老是血管系统老化的标志,易导致各种心血管疾病(CVD)的发病,更好。
and CD44- and CD133-highly-expressing cells were reported to exhibit stem cell-like properties and resistance to 5-FU15. In CSC-like cells, one drug resistance mechanism, with respect to 5-FU and other drugs, was reported to be partially dependent on TRAIL-induced death cell, which was in...