1.2.3 CD44V的特征:目前发现10个V外显子编码的氨基酸中有约30%的丝、苏氯酸残基,具有广泛潜在O-糖基化位点,如:V6具有潜在的O-糖基化位点。V3外显子序列分析中发现Ser-Gly-Ser-Gly片段,它可结合硫酸肝素,结合硫酸肝素后的CD44V能与碱性成纤维细胞生长因子(b-FGF)结合肝素的表皮生长(HBEGF)因子结合,此结果...
DEN administration and liver damage induce the expression of numerous EGFR ligands, including EGF, HB-EGF, epiregulin, betacellulin, and transforming growth factor α, as well as the c-Met ligand hepatocyte growth factor (HGF), most of which are mainly expressed by liver macrophages (Fuchs et...
Moreover, the heparin-sulfated CD44v3 isoform is required for HB-EGF-induced EGFR signaling. These data suggest that specific CD44 isoforms are recruited in a ligand-dependent manner as co-receptors in the EGFR signaling pathways and that the specificity is determined by the ligand and not by ...
CD44 promoter activity comparison among different treatment of cytokines groups. TGFβ, HGF, IL-6, IGF1, and EGF treated on CFPAC-1 CD44 low cells.TGFβtransforming growth factor β,HGFhepatocyte growth factor,IL-6interleukin-6,IGF1insulin-like growth factor 1,EGFepidermal growth factor Full si...
85, 86, 87, 88 (2) Certain cytokines (ie, MIP-1β, β-FGF, and HB-EGF) bind glycosaminoglycans, increasing the possibility that glycosaminoglycans on CD44 might compete with cytokines and, therefore, regulate cytokine binding to surrounding cells. (3) CD44 may immobilize cytokines directly on...
１．１Ｃｎ；基因的定位与结构ＣＤ４。是细胞表面的跨膜糖蛋白，基因位于１１号染色体短臂上，由２０个高度保守的外显子组成，完整的基因组在染色体ＤＮＡ上大约跨越５０ｋｂ。ＣＤ４；基因的外显子按表达方式可分为两种类型；一种是标准型ＣＤ４。（Ｃ眈。ｓ），含固定表达的ｌｏ个组成型外显子，共有３６１...
For example, the v3-containing heparan sulphated CD44 isoforms (CD44v3) bind growth factors such as HB-EGF or b-FGF.3 During limb development such a specific heparan sulphated isoform is expressed in cells of the apical ectodermal ridge and is involved in the presentation of FGF to its ...
(b—FGF)结合,与肝素的表皮生长因子(HB—EGF) 结合,提示这种CD参与了传递细胞因子的过程 1.3 CD基因的功能 CD蛋白参与同周围细胞 和细胞外间质成分如HA、纤维连接蛋白、硫酸软骨 素等的黏附作用;介导淋巴细胞与高内皮小静脉 (HEV)的内皮细胞结合,使淋巴细胞归巢,激活淋 ...
TGFβ transforming growth factor β, HGF hepatocyte growth factor, IL-6 interleukin-6, IGF1 insulin-like growth factor 1, EGF epidermal growth factor Full size image CD44 expression is also linked to β-catenin and AKT pathways in breast cancer and cervical cancer cells. Inhibition of both β...
CD44的胞外功能区被广泛地N-和O-糖基化修饰,从而影响透明质酸HA对CD44剪接体的结合能力,如CD44v3在被软骨素硫酸盐修饰后能使CD44变成肝素硫酸盐黏蛋白进而结合许多生长因子,如b-FGF[3]、VEGF[4]和HBEGF。CD44的细胞质尾区能结合埃兹蛋白-根蛋白-膜突蛋白(ERM)[5]和锚定蛋白(ankyrin)[6],进而和细胞骨架...