However, CD44 knockdown in SNU354 cells did not induce EMT even after treatment with TGF-beta 1. Finally, double inhibition of both CD44 and TGF-beta 1 further decreased migration and sphere formation more strongly than a single inhibition in SNU-368 cells. In conclusion, the current study ...
The TGFβ2 is identified as a CD44 downstream target that promotes EMT and breast cancer invasion. TGF-β2 was upregulated when CD44 was induced; inhibition of CD44 gene by RNAi decreased TGF-β2 expression upon HA-stimulation and subsequently inhibited cell invasion in vitro [135]. Activation...
我们的资料表明,正常喉粘膜CD44V6蛋白和TGFβ表达均为阴性,喉鳞状细胞癌CD44V6蛋白表达率为52%,TGFβ表达率为77%。CD44V6蛋白和TGFβ阳性表达与喉癌发生部位、组织学分级和临床分期无关,颈淋巴结转移的40例CD44V6蛋白和TGFβ阳性表达分别为60%和65%,无淋巴结转移的29例阳性率分别为28%及34%,且差异有显著意义。
TGF-beta2: a novel target of CD44-promoted breast cancer invasion. J Cancer. 2013;4(7):566–72. Article PubMed PubMed Central CAS Google Scholar Zhang J, Liang Q, Lei Y, Yao M, Li L, Gao X, Feng J, Zhang Y, Gao H, Liu DX, et al. SOX4 induces epithelial-mesenchymal ...
CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta J Immunol, 183 (2009), pp. 2232-2241 CrossrefView in ScopusGoogle Scholar 52 G.J. Martinez, Z. Zhang, Y. Chung, J.M. Reynolds, X. Lin, A.M. Jetten, X.H...
In this study we have examined the interaction between CD44 (a hyaluronan (HA) receptor) and the transforming growth factor beta (TGF-beta) receptors (a family of serine/threonine kinase membrane receptors) in human metastatic breast tumor cells (MDA-MB-231 cell line). Immunological data indicat...
货号MHCD4404 View price in cart 0.5 mL 下单后预计有货时间 15-Apr-2025 查看价格 批量或定制请求 Application Created with Sketch. 图:1/2 CD44 Antibody (MHCD4404) in Flow PLoS medicine 2015 -Fig 4 Asporin binds to TGF-beta1 and inhibits its downstream signaling and function. (A) Western...
(yellow line). Moreover, the interaction between HA and CD44v6 increases the production of MMP2/9, which degrades ECM along with promoting maturation of TGFβ (see ref.61). After acting on its receptor, Smad3 will stabilize β-catenin intracellularly together with activated Akt. Then, the ...
TGFBR3 TGF-beta RIII/TGFBR3 protein, recombinant CD44 蛋白的序列 种属Human CD44 proteinMouse CD44 proteinRat CD44 protein Length 742 778 503 Mass (Da) 81538 85617 55946 Sequence Human CD44 protein sequence Mouse CD44 protein sequence Rat CD44 protein sequence CD44 蛋白分子量&等电点 CD44 ...
川芎嗪调节TGF-β1_Smad信号通路对哮喘小鼠气道炎症和气道重塑的影响 热度: 大气PM2.5对哮喘大鼠肺组织组蛋白乙酰化的影响及其机制研究 热度: · 174 · 现代医学(ModemMedicalJourna1),2005年6月,第33卷 第3期 ·论 著· 川芎嗪对哮喘大鼠肺组织CD44 ...