However, CD44 knockdown in SNU354 cells did not induce EMT even after treatment with TGF-beta 1. Finally, double inhibition of both CD44 and TGF-beta 1 further decreased migration and sphere formation more strongly than a single inhibition in SNU-368 cells. In conclusion, the current study ...
The TGFβ2 is identified as a CD44 downstream target that promotes EMT and breast cancer invasion. TGF-β2 was upregulated when CD44 was induced; inhibition of CD44 gene by RNAi decreased TGF-β2 expression upon HA-stimulation and subsequently inhibited cell invasion in vitro [135]. Activation...
TGF-beta2: a novel target of CD44-promoted breast cancer invasion. J Cancer. 2013;4(7):566–72. Article PubMed PubMed Central CAS Google Scholar Zhang J, Liang Q, Lei Y, Yao M, Li L, Gao X, Feng J, Zhang Y, Gao H, Liu DX, et al. SOX4 induces epithelial-mesenchymal ...
invasion, and metastasis. Furthermore, HA promotes the phosphorylation of the cytoplasmic domain of CD44v6, which then activates Ras and FAK through Src, thus resulting in activation of MAPK/ERK signaling pathway (red line). Likewise, the interaction between HA and CD44v6 also activates the PI3K...
TGFBR3 TGF-beta RIII/TGFBR3 protein, recombinant CD44 蛋白的序列 种属Human CD44 proteinMouse CD44 proteinRat CD44 protein Length 742 778 503 Mass (Da) 81538 85617 55946 Sequence Human CD44 protein sequence Mouse CD44 protein sequence Rat CD44 protein sequence CD44 蛋白分子量&等电点 CD44 ...
CD44V6蛋白及TGFβ阳性表达产物主要位于细胞浆中,20例正常喉粘膜CD44V6蛋白、TGFβ表达均为阴性。69例喉鳞癌CD44V6蛋白、TGFβ阳性率分别为52%(36/69),77%(53/69)。40例伴有颈部淋巴结转移的CD44V6蛋白阳性率为60%(24/40),TGFβ阳性率为65%(26/40),29例无淋巴结转移CD44V6蛋白阳性表达阴性率为28%(8/29...
In this study we have examined the interaction between CD44 (a hyaluronan (HA) receptor) and the transforming growth factor beta (TGF-beta) receptors (a family of serine/threonine kinase membrane receptors) in human metastatic breast tumor cells (MDA-MB-231 cell line). Immunological data indicat...
货号MHCD4404 View price in cart 0.5 mL 下单后预计有货时间 15-Apr-2025 查看价格 批量或定制请求 Application Created with Sketch. 图:1/2 CD44 Antibody (MHCD4404) in Flow PLoS medicine 2015 -Fig 4 Asporin binds to TGF-beta1 and inhibits its downstream signaling and function. (A) Western...
CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta J Immunol, 183 (2009), pp. 2232-2241 CrossrefView in ScopusGoogle Scholar 52 G.J. Martinez, Z. Zhang, Y. Chung, J.M. Reynolds, X. Lin, A.M. Jetten, X.H...
Tian Y, Phillips AO (2003) TGF-beta1-mediated inhibition of HK-2 cell migration. J Am Soc Nephrol 14(3):631–640 Article PubMed CAS Google Scholar Oliferenko S, Kaverina I, Small JV, Huber LA (2000) Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgr...