2.Nakajima Y, Chamoto K, Oura T, Honjo T. Critical role of the CD44(low)CD62L(low) CD8(+) T cell subset in restoring antitumor immunity in aged mice.Proc Natl Acad Sci U S AJun 8 2021;118(23).doi:10.1073/pnas.2103730118. 3.Kugel CH, 3rd, Douglass SM, Webster MR, et al. ...
CD44, a receptor for the extracellular matrix component hyaluronan, is a marker of activated and memory T cells. Here, we show with a murine model that the increase in CD44 expression and hyaluronan binding induced upon CD8 T cell activation was proportional to the strength of TCR engagement, ...
2.有一些marker可以表征这种动态变化过程 根据表型,功能及转录因子,目前CD8+T细胞可以进一步分为以下不同的亚群: Tnaive CD44-CD62+ T SCM :干细胞记忆T细胞(Stem cell memory T cell) T EM:效应记忆T细胞(Effector memory T Cell):CD44+CD62L- T CM:中枢记忆T细胞(Central memory T Cell):CD44+CD62L+ T...
Graft versus host disease (GVHD) is triggered by host antigen-presenting cells (APCs) that activate donor T cells to proliferate and differentiate, but which APC-activated donor T-cell subsets mediate GVHD versus beneficial antitumor effects is not known. Using a CD8+ T cell–dependent mouse mod...
Infusion of CD8+ memory T cells after transplantation was able to eradicate the BCL1 lymphoma even after progressive growth without inducing severe GVHD. In conclusion, the memory CD8+ T-cell subset separated graft antilymphoma activity from GVHD more effectively than naive T cells, memory CD4+ ...
Non-Hematopoietic Antigen Blocks Early Memory Imprinting Of Graft-Versus-Host Reactive CD8 Cells Donor T cell alloreactivity can be co-opted to deliver a graft-versus-tumor (GVT) response following blood or bone marrow transplantation (BMT). However, the major reason for treatment failure following...
Cell Surface Flow Cytometry Staining Protocol Related Pages & Pathways Pathways CD4 and CD8 T-Cell Lineage Gamma-Delta T cells Stem Cells and Development T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) TH2 Pathway (Humoral Immune Response) Pages Quality Control ...
Cell Staining Buffer FC,ICC,ICFC Alexa Fluor® 647 Rat IgG2b, κ Isotype Ctrl RTK4530 FC,ICFC TruStain FcX™ PLUS (anti-mouse CD16/32) S17011E FC Compensation Beads FC Related Pages & Pathways Pathways CD4 and CD8 T-Cell Lineage Gamma-Delta T cells Stem Cells and Development ...
K. Cells help induce anti-hepatitis B virus CD8+ T cell immunity in mice. J. Immunol. 196, 4122–4131 (2016). Article CAS Google Scholar Mackay, L. K. et al. Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen ...
CD4+CD8+double-positive (DP) T-cells depletion due to apoptosis. The viruses were present in thymus, where they activated thymic innate CD8+CD44hisingle-positive (SP) thymocytes to secrete a large amount of IFN-γ. Milder thymic atrophy was observed in innate CD8+T-cell-deficient mice (C57...