Anti-CD44 treatment alone delayed diabetes onset and increased the frequencies of pancreatic CD4+ T cells producing IL-2 or TGF-尾, cytokines that support Treg function and survival, without altering production of IFN-纬. These anti-CD44 effects on endogenous T cells were also observed in the ...
基于癌症免疫周期,CD44与细胞抗原的释放,启动和激活,CD4 T细胞,CD8 T细胞,Th1细胞,Th2细胞,Th17细胞,Th22细胞,Th2细胞,Treg细胞,B细胞,嗜酸性粒细胞,中性粒细胞,树突状细胞,巨噬细胞,NK细胞的募集以及多种免疫细胞的浸润呈正相关(图2B)。 此外,CD44与多种代谢途径呈正相关,包括糖原生物合成、半乳糖代谢、糖胺...
病原体特异性 CD4 Teff(和 Tmem)细胞可根据其表型和功能分为多个 T“辅助”(Th)亚群:Th1、Th2、Th9、Th17、Th22、细胞毒CD4+T细胞和Tfh。除了这些传统的 CD4 Th 细胞亚群外,天然和诱导的 Treg 细胞也是大家经常研究的对象,小鼠Treg具有免疫调节表型,能够...
eTreg通过通过Icos进行信号传递来维持(604558)。Smigiel等(2014年)得出结论,基于Treg人群在不同环境中的定位和信号传导机制,Treg人群存在基本的稳态细分。 瓦伦丁等(2011)发现全长重组FKBPL(617076)的表达在体外和体内抑制了HMEC-1正常人内皮细胞的迁移,小管形成和微血管形成。在刮伤试验中,纯化的FKBPL的外源给药也以...
CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion. T-cell tolerance to tumor antigens represents a major hurdle in generating tumor immunity. Combined administration of agonistic monoclonal antibodies (mAbs... Marie-Clare,S Rose,A Roslyn,.....
degree of differentiation and lymph Table 2 The correlation between CD44 and T-cell gene markers was analysed by using the TIMER database Description Gene markers STAD None Purity Cor P Cor P Th1 Th1-like Th2 Treg Resting Treg Effector Treg T-cell Effector T-cell Native T-cell Effecto...
Effector/memory T cells (Tem) are required to maintain successful immunity, while regulatory T cells (Treg) are required to prevent excessive/uncontrolled inflammation and/or autoimmunity. Although both Tem and Treg cells are increased during aging, the relationship between the increased proportion of...
expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte ...
Regulatory T cells (Treg) ar... C Loddenkemper,M Schernus,M Noutsias,... - 《Journal of Translational Medicine》 被引量: 201发表: 2006年 Immunological commonalities and distinctions between airway and digestive immunity Airway and digestive tissues are the frontlines of the body's defense, ...
expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte ...