Elimination of the major non-CD4+ splenic cell types significantly impacted the peripheral recovery of Treg cell frequencies in recipients of the high-dose inoculum, but had no effect on the numbers of Treg cells in mice receiving the low dose of CD4+CD25− cells. The two-fold increase of...
Resting Regulatory CD4 T Cells: A Site of HIV Persistence in Patients on Long-Term Effective Antiretroviral Therapy In HIV-infected patients on long-term HAART, virus persistence in resting long-lived CD4 T cells is a major barrier to curing the infection. Cell quiescenc... TA Tran,MGDGD He...
The resting CD4 þ CD26À T cells in NSHL showed higher mRNA levels of CD25, CTLA4, OX40 and CCR4 compared with in LNs, supporting a regulatory T-cell (Treg) type, and this was validated by immunohistochemistry. Moreover, these cells showed low or no expression of the Th1- or Th...
Persistent human immunodeficiency virus type 1 (HIV-1) infection of resting CD4 T cells, unaffected by antiretroviral therapy (ART), provides a long-lived reservoir of HIV infection. Therapies that target this viral reservoir are needed to eradicate HIV-1 infection. A small-animal model that reca...
Importantly, CD4+CD25+ Treg cells exposed to HIV were not susceptible to homing-induced apoptosis like are other resting CD4+ cells following HIV-1 binding. We show that CD4+CD25+ Treg cells respond directly to HIV-1 itself through HIV gp120 interactions with CD4 molecules. Collectively, our ...
Importantly, CD4+CD25+ Treg cells exposed to HIV were not susceptible to homing-induced apoptosis like are other resting CD4+ cells following HIV-1 binding. We show that CD4+CD25+ Treg cells respond directly to HIV-1 itself through HIV gp120 interactions with CD4 molecules. Collectively, our ...
Increased proportions of Treg cells among CD4+ T cells of CD4ΔIl7ra mice. (A) Representative flow cytometry plots of CD4+Foxp3+ cells in gated CD4+ T cells at EAE peak in CD4ΔIl7ra and control mice. (B) A total number of CD4+Foxp3+ T cells in the CNS, LNs, and spleen of ...
Foxp3 ghf Ⅱ区)细 胞具 有 免疫 抑制 活性 ,属于 活化 的 Treg 细胞 (activated Treg cells ,aTreg) 而 CD45RA Foxp3 f I xE )是一群源 自胸 腺 的初 始 T 细胞 ,属于 静 息期 Treg 细胞 (resting Treg cells ,rTreg) ,aTreg 细 胞在体内发挥抑制作用后即死亡 .主要由 rTreg 细...
Resting and activated subpopulations of CD4+CD25+CD127loT regulatory cells (Treg) and CD4+CD25+CD127+ effector T cells in MS patients and in healthy individuals were compared. Peripheral blood mononuclear cells isolated using Ficoll Hypaque were stained
Depletion of these Treg-like cells increased nonspecific cytotoxic cell activity, mixed lymphocyte reaction, and intestinal inflammation [7], a manner reminiscent of the actions of mammalian Treg cells. In zebrafish, foxp3+ CD4-enriched T cells have been identified [40]. Zebrafish foxp3a mutant ...